Synthesis and evaluation of new magneto-fluorescent carbon dot based on manganese citrate for MRI imaging.

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Magnetic Resonance Materials in Physics, Biology and Medicine Pub Date : 2024-02-01 Epub Date: 2023-10-20 DOI:10.1007/s10334-023-01117-8
Vahid Ali, Hassan Kefayati, Mehdi Shafiee Ardestani, Afshin Pourahmad
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引用次数: 0

Abstract

Objective: Medical imaging techniques have widely revolutionized the diagnosis and treatment of various health conditions. Among these techniques, magnetic resonance imaging (MRI) has stood out as a noninvasive and versatile tool. Now, a breakthrough innovation called "manganese-carbon dots" is poised to enhance MRI imaging and provide physicians with even greater insight into the human body.

Materials and methods: In this study, one-pot hydrothermal method was used to fabricate magneto-fluorescent carbon quantum dots using manganese citrate, urea, and Mn2+. Manganese citrateAQ3 acted as a carbon source and contrast agent. TEM,XPS, FTIR, UV-Vis, fluorescent analysis confirmed the successful synthesis of magneto-fluorescent carbon quantum dots. The MTT assay was used to study its biocompatiblity, Finallay application of itscompound for mri imaging was investigated.

Results: Characterization Techniques confirmed the succesful synthesis of product. MTT assay showed no toxicity of this product on HEK-293 cells. In addition, it exhibited high r1 relaxivity (7.4 mM-1 S-1) suggesting excellent potential of magneto-fluorescent carbon quantum dots as MRI T1 contrast agent and enabling specific imaging.

Conclusion: Based on the results obtained, the synthesized carbon quantum dots could be used as fluorescence/MRI bimodal platform for in vivo imaging.

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基于柠檬酸锰的新型磁荧光碳点的合成与评价。
目的:医学影像技术已经广泛地改变了各种健康状况的诊断和治疗。在这些技术中,磁共振成像(MRI)作为一种非侵入性和多功能的工具脱颖而出。现在,一种名为“锰碳点”的突破性创新有望增强MRI成像,并为医生提供对人体更深入的了解。材料和方法:本研究采用一锅水热法,用柠檬酸锰、尿素和Mn2+制备了磁荧光碳量子点。柠檬酸锰AQ3作为碳源和造影剂。TEM、XPS、FTIR、UV-Vis、荧光分析证实了磁荧光碳量子点的成功合成。采用MTT法研究其生物相容性,最后探讨其化合物在mri成像中的应用。结果:表征技术证实了产物的成功合成。MTT法检测该产物对HEK-293细胞无毒性。此外,它表现出高的r1弛豫性(7.4mM-1 S-1),这表明磁荧光碳量子点作为MRI T1造影剂具有良好的潜力,并且能够进行特异性成像。结论:基于所得结果,合成的碳量子点可作为体内成像的荧光/MRI双峰平台。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: MAGMA is a multidisciplinary international journal devoted to the publication of articles on all aspects of magnetic resonance techniques and their applications in medicine and biology. MAGMA currently publishes research papers, reviews, letters to the editor, and commentaries, six times a year. The subject areas covered by MAGMA include: advances in materials, hardware and software in magnetic resonance technology, new developments and results in research and practical applications of magnetic resonance imaging and spectroscopy related to biology and medicine, study of animal models and intact cells using magnetic resonance, reports of clinical trials on humans and clinical validation of magnetic resonance protocols.
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