The Role of [18F]FDG-PET/CT in Predicting Malignant Transformation of Plexiform Neurofibromas in Neurofibromatosis-1

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2016-12-12 DOI:10.1155/2016/6162182
D. Tovmassian, Muzib Abdul Razak, K. London
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引用次数: 49

Abstract

Background. Malignant peripheral nerve sheath tumours (MPNSTs) are difficult to diagnose and treat and contribute to significant morbidity and mortality for patients with Neurofibromatosis-1 (NF-1). FDG-PET/CT is being increasingly used as an imaging modality to discriminate between benign and malignant plexiform neurofibromas. Objectives. To assess the value of FDG-PET/CT in differentiating between benign and malignant peripheral nerve lesions for patients with Neurofibromatosis-1. Methods. A systematic review of the literature was performed prior to application of stringent selection criteria. Ultimately 13 articles with 796 tumours were deemed eligible for inclusion into the review. Results. There was a significant difference between mean SUVmax of benign and malignant lesions (1.93 versus 7.48, resp.). Sensitivity ranged from 89 to 100% and specificity from 72 to 94%. ROC analysis was performed to maximise sensitivity and specificity of SUVmax cut-off; however no clear value was identified (range 3.1–6.1). Significant overlap was found between the SUVmax of benign and malignant lesions making differentiation of lesions difficult. Many of the studies suffered from having a small cohort and from not providing histological data on all lesions which underwent FDG-PET/CT. Conclusion. This systematic review is able to demonstrate that FDG-PET/CT is a useful noninvasive test for discriminating between benign and malignant lesions but has limitations and requires further prospective trials.
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[18F]FDG-PET/CT在预测神经纤维瘤病丛状神经纤维瘤恶性转化中的作用[j]
背景。恶性周围神经鞘肿瘤(MPNSTs)难以诊断和治疗,并导致神经纤维瘤病-1 (NF-1)患者的显著发病率和死亡率。FDG-PET/CT越来越多地被用作区分良性和恶性丛状神经纤维瘤的成像方式。目标。目的探讨FDG-PET/CT对神经纤维瘤病患者周围神经良恶性病变的鉴别价值。方法。在应用严格的选择标准之前,对文献进行了系统的回顾。最终,13篇涉及796个肿瘤的文章被认为有资格纳入该综述。结果。良性和恶性病变的平均SUVmax差异有统计学意义(分别为1.93和7.48)。敏感性为89% ~ 100%,特异性为72% ~ 94%。进行ROC分析以最大化SUVmax截止值的敏感性和特异性;然而,没有明确的数值(范围3.1-6.1)。良性和恶性病变的SUVmax之间存在明显的重叠,使得病变的鉴别变得困难。许多研究的缺点是队列小,而且没有提供所有经FDG-PET/CT检查的病变的组织学数据。结论。本系统综述能够证明FDG-PET/CT是一种有用的非侵入性检测方法,用于区分良性和恶性病变,但存在局限性,需要进一步的前瞻性试验。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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