A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma.

IF 1.6 Q4 ONCOLOGY International Journal of Surgical Oncology Pub Date : 2016-01-01 Epub Date: 2016-02-17 DOI:10.1155/2016/6347136
Anthony Kodzo-Grey Venyo
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引用次数: 27

Abstract

Background: Extrarenal retroperitoneal angiomyolipomas are rare.

Aim: To review the literature.

Results: Angiomyolipomas, previously classified as hamartomas, are now classified as benign tumours. Thirty cases of primary retroperitoneal angiomyolipomas have been reported. Diagnosis of the disease upon is based radiological and pathological findings of triphasic features of (a) fat and (b) blood vessels and myoid tissue. Immunohistochemistry tends to be positive for HMB45, MART1, HHF35, calponin, NKI-C3, and CD117. The lesion is common in women. Treatment options have included the following: (a) radical surgical excision of the lesion with renal sparing surgery or radical nephrectomy in cases where malignant tumours could not be excluded and (b) selective embolization of the lesion alone or prior to surgical excision. One case of retroperitoneal angiomyolipoma was reported in a patient 15 years after undergoing radical nephrectomy for angiomyolipoma of kidney and two cases of distant metastases of angiomyolipoma have been reported following radical resection of the tumour.

Conclusions: With the report of two cases of metastases ensuing surgical resection of the primary lesions there is need for academic pathologists to debate and review angiomyolipomas to decide whether to reclassify angiomyolipomas as slow-growing malignant tumours or whether the reported cases of metastases were de novo tumours or metastatic lesions.

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肾外腹膜后血管瘤文献综述
背景:肾外腹膜后血管肌脂肪瘤非常罕见:目的:回顾文献:结果:血管肌脂肪瘤以前被归类为hamartomas,现在被归类为良性肿瘤。已有 30 例原发性腹膜后血管肌脂肪瘤的报道。该病的诊断依据是放射学和病理学发现的(a)脂肪和(b)血管及肌层组织的三相特征。免疫组化结果显示,HMB45、MART1、HHF35、calponin、NKI-C3 和 CD117 呈阳性。这种病变常见于女性。治疗方法包括以下几种:(a) 对病灶进行根治性手术切除,在无法排除恶性肿瘤的情况下进行保肾手术或根治性肾切除术;(b) 单独或在手术切除前对病灶进行选择性栓塞。有报告称,一名患者因肾脏血管脂肪瘤接受根治性肾切除术 15 年后出现腹膜后血管脂肪瘤,还有报告称,两例血管脂肪瘤患者在接受肿瘤根治性切除术后出现远处转移:结论:随着两例原发病灶手术切除后转移病例的报道,学术界病理学家有必要对血管脂肪瘤进行讨论和审查,以决定是否将血管脂肪瘤重新归类为生长缓慢的恶性肿瘤,或者所报道的转移病例是新发肿瘤还是转移病灶。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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