Intravaginal Administration of Sildenafil Citrate Increases Blood Flow in the Bovine Uterus

M. Dzięcioł, A. Noszczyk-Nowak, Katarzyna Michlik, W. Niżański, G. Dejneka
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Abstract

Abstract The aim of the study was to evaluate the influence of sildenafil citrate administrated intravaginaly on the blood flow in the bovine uterus during dioestrus. Uterine blood flow was examined in six healthy adult cows. Sildenafil was administrated intravaginaly to each co w between the 6th and 8th d of the ovarian cycle, in the form of vaginal suppositories containing 100 mg of active substance at a dose of 100, 200, or 300 mg per animal. Uterine perfusion was estimated by the colour Doppler examination, and obtained results were analysed with the Pixel Flux Software (Chameleon, Germany). Moreover, cardiovascular parameters were also evaluated. Animals were examined before and five times after drug application (two times at 15 min intervals, and three times at 2 h intervals). A placebo suppository was also given to the cows. The analysis of the intensity and velocity of blood flow in the uterus proved that sildenafil administrated intravaginaly significantly increased blood flow in the uterus and the effect of increased perfusion was observed for 4 h and 30 min after administration. The effect of increased uterine perfusion was observed after low as well as high doses of sildenafil. Significant changes in the cardio-vascular parameters were not detected. There were no changes in the uterine perfusion as well as in cardiovascular parameters after placebo administration.
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阴道内给予枸橼酸西地那非增加牛子宫的血流量
摘要本研究旨在探讨经阴道给药枸橼酸西地那非对牛排卵期子宫血流的影响。对6头健康成年奶牛进行子宫血流检查。西地那非在卵巢周期的第6天至第8天以阴道栓剂的形式经阴道内给药,其中含有100毫克活性物质,每只动物的剂量为100、200或300毫克。通过彩色多普勒检查估计子宫灌注,并使用像素通量软件(变色龙,德国)分析所得结果。此外,还评估了心血管参数。动物在给药前和给药后检查5次(间隔15 min 2次,间隔2 h 3次)。研究人员还给奶牛注射了安慰剂栓剂。子宫血流强度和速度分析表明,阴道内给药西地那非明显增加子宫血流,并在给药后4 h和30 min观察增加灌注的效果。观察低剂量和高剂量西地那非对子宫灌注增加的影响。未发现心血管参数有明显变化。服用安慰剂后,子宫灌注和心血管参数均无变化。
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