Cancer Cells Shed Micro-Vesicles from Actin Stress Fibres - a New Cooperative Mechanism for Metastasis?

Abstract

Since decades cancer therapy has made slow but continuous strides in fighting primary tumors, but progress in the suppression of metastasis remains elusive. The spread of cancer to distant locations in the body is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Although cancer survival rate has been significantly improved over the years, the improvement is primarily due to early diagnosis and cancer growth inhibition (Guan X, 2015) [1].