Expression of Ki-67 and its relationship with the histological grade of Endometrial Stromal Sarcomas

Abstract

Objective To study the expression of Ki-67 and its relationship with the histological grade of Endometrial Stromal Tumors. Methods Immunohistochemical EnVision method was applied to detect the expression of Ki-67 expression in 24 cases of Endomertrial stromal sarcoma( ESS), and 12 cases of Undifferentiated endometrial sarcoma(UESs) ,and its relationship with the risk rank was analyzed. Results The Ki-67 nuclear antigen in ESSs were 38% which were lower than 87% in UESs( P < 0.05 ). There was posive correlation of Ki-67 with histolegical grade between ESS and UES. Conclusion The expression of Ki-67 might be important biological markers for histolegical grade of ESSs. Key words: Endometrial stromal sarcoma;  Ki-67 nuclear antigen; Grade