The immune response to SARS-CoV-2. Focus on severe COVID-19 pathogenesis

R. Pawliczak
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引用次数: 3

Abstract

SARS-CoV-2 pandemics increased research in the interaction of coronaviruses with human immune response Moreover, a detailed analysis of SARS-CoV-2 immune response might be helpful in vaccine development and delivering some other therapeutic approaches Several papers described SARS and MERS antiviral response Unfortunately, not all data derived from SARS and MERS studies could be directly applied to the SARS-CoV-2 immune response, its clinical course and severe COVID-19 pathology In this paper we are trying to summarize basic aspects of COVID-19 immunopathology focusing on immune response, pathogenesis of severe disease and the differences between SARS-CoV-2 and its predecessors Moreover, we are trying to outline possible therapeutic approaches including but not limited to vaccines All reviewed data have to be treated with caution Next months and years will generate more results helping us to deal with SARS-CoV-2, which will confirm or disprove current information and the understanding of COVID-19
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对SARS-CoV-2的免疫反应。重点关注重症COVID-19发病机制
此外,对SARS- cov -2免疫反应的详细分析可能有助于疫苗开发和提供一些其他治疗方法。几篇论文描述了SARS和MERS的抗病毒反应。不幸的是,并非所有从SARS和MERS研究中获得的数据都可以直接应用于SARS- cov -2免疫反应。在本文中,我们试图总结COVID-19免疫病理学的基本方面,重点是免疫反应,严重疾病的发病机制以及SARS-CoV-2与前代病毒的区别。此外,我们试图概述可能的治疗方法,包括但不限于疫苗。所有审查的数据都必须谨慎对待。接下来的几个月和几年将产生更多的结果,帮助我们应对SARS-CoV-2。哪些将证实或反驳当前的信息和对COVID-19的理解
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来源期刊
自引率
50.00%
发文量
18
期刊介绍: Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.
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