{"title":"Genome editing in therapy: immunological context","authors":"P. Rieske","doi":"10.5114/pja.2021.111801","DOIUrl":null,"url":null,"abstract":"obie-cujące lub mukowiscydozie. Edycja genomu autogennych T z chimerycznym receptorem antygenowym ( chimeric antigen receptor T-cells – CAR-T). Edycja genomu w połączeniu z technologią iPSc powinna umożliwić otrzymanie tzw. uniwersalnych komórek do transplantacji, w tym uniwersalnych CAR-T. Edycja genomu jest więc szczególnie istotna kontekście immunologicznym. abStract Genome editing of induced pluripotent stem cells (iPSc) or hematopoietic tolerancji immunologicznej, ale ta zmienna jest istotna [4, 5]. Chorób warunkowanych występowaniem mutacji typu nonsens jest wiele, symptoms depend on blood cell dysfunction than, for example, in muscular dystrophy or cystic fibrosis. Genome editing is also used to refine autogenous T cells with chimeric antigen receptor T-cells (CAR-T). Finally, genome editing in combination with iPSc technology should enable the production of the so-called universal for transplantation, including universal CAR-T. Genome editing is therefore particularly important in an immunological context.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alergologia Polska - Polish Journal of Allergology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/pja.2021.111801","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0
Abstract
obie-cujące lub mukowiscydozie. Edycja genomu autogennych T z chimerycznym receptorem antygenowym ( chimeric antigen receptor T-cells – CAR-T). Edycja genomu w połączeniu z technologią iPSc powinna umożliwić otrzymanie tzw. uniwersalnych komórek do transplantacji, w tym uniwersalnych CAR-T. Edycja genomu jest więc szczególnie istotna kontekście immunologicznym. abStract Genome editing of induced pluripotent stem cells (iPSc) or hematopoietic tolerancji immunologicznej, ale ta zmienna jest istotna [4, 5]. Chorób warunkowanych występowaniem mutacji typu nonsens jest wiele, symptoms depend on blood cell dysfunction than, for example, in muscular dystrophy or cystic fibrosis. Genome editing is also used to refine autogenous T cells with chimeric antigen receptor T-cells (CAR-T). Finally, genome editing in combination with iPSc technology should enable the production of the so-called universal for transplantation, including universal CAR-T. Genome editing is therefore particularly important in an immunological context.
期刊介绍：
Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.
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