Novel synthesis of phthalazine derivatives as antimicrobial agents

Y. Issac, Eman El-Karim, S. Donia, Mohamed Behalow
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引用次数: 19

Abstract

Reaction of 4-(phenoxathiin-2-yl)-1-oxy or mercaptophthalazines 2a,c with phthalyl or tosylamino acids 3 and 4 has been found to yield 5,6a-j . Hydrazinolysis of 5,6a-e furnished amino derivatives 5,6k-o . Some of the newly synthesized products were tested for their antimicrobial activities.
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新型酞嗪类抗菌药物的合成
4-(2-基苯氧嘧啶)-1-氧或巯基酞嗪2a,c与邻苯二甲酸或苯三胺酸3和4反应得到5,6a-j。含5,6a-e的氨基衍生物5,6k-o的肼解。对部分新合成产物进行了抗菌活性测试。
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