Association of Serum Magnesium Levels with Matrix metalloproteinase-9 (MMP-9) Urine in Patients with Diabetic Kidney Disease Stage 1 and 2

M. H. Rafsanjani, S. Wibisono, Chandra Irwanadi
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Abstract

Introduction: The progressiveness of stage 1 and 2 kidney disease is indicated by an increase in matrix metalloproteinase-9 (MMP-9). Development of diabetic kidney disease (DKD) is characterized by a thuckening of the glomerular basement membrane followed ultimately by progression to glomerular sclerosis and fibrosis. One of the factors that contribute is magnesium levels. This study aimed to determine the association between serum magnesium levels and MMP-9 urine in patients with stage 1 and 2 DKD.Methods: This was a cross sectional study from stage 1 and 2 DKD patients. Patients were examined for serum magnesium levels and urine MMP-9. Urine MMP-9 examination was taken from the middle portion urine collection and examined using Sandwich-ELISA method then normalized with urine creatinine. The correlation between magnesium and MMP-9 urine was analyzed by the Spearman rank test.Results: This study involved 56 subjects. The mean serum magnesium level was 1.8 ± 0.26 mg/dL. The mean MMP-9 was 120 ng/g creatinin. The mean value of FBG (fasting blood glucose) in patients in the study was 153.29±50.22 mg/dL. The mean value of PPG (post prandial glucose) was 233.61±71.3 mg/dL. The mean HbA1c value was 7.6±1.13%. The mean creatinin serum value was 1.1±0.43 mg/dL. There was a significant negative relationship with a moderate correlation between serum magnesium levels and urine MMP-9 (p = 0.000, r -0.512).Conclusion: There was a significant negative relationship between serum magnesium levels and urine MMP-9 in stage 1 and 2 DKD patients.
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1期和2期糖尿病肾病患者血清镁水平与尿基质金属蛋白酶-9 (MMP-9)的关系
1期和2期肾脏疾病的进展是由基质金属蛋白酶-9 (MMP-9)升高所指示的。糖尿病肾病(DKD)的特点是肾小球基底膜增厚,最终发展为肾小球硬化和纤维化。其中一个因素是镁含量。本研究旨在确定1期和2期DKD患者血清镁水平与尿MMP-9之间的关系。方法:这是一项来自1期和2期DKD患者的横断面研究。检测患者血清镁水平和尿MMP-9。取中段尿液进行MMP-9检测,采用夹心elisa法检测,然后用尿肌酐归一化。通过Spearman秩检验分析镁与尿MMP-9的相关性。结果:本研究共涉及56名受试者。血清镁平均水平为1.8±0.26 mg/dL。平均MMP-9为120 ng/g creatinin。本研究患者空腹血糖平均值为153.29±50.22 mg/dL。PPG(餐后血糖)平均值为233.61±71.3 mg/dL。HbA1c平均值为7.6±1.13%。血清创造素平均值为1.1±0.43 mg/dL。血清镁水平与尿MMP-9呈正相关,呈显著负相关(p = 0.000, r -0.512)。结论:1、2期DKD患者血清镁水平与尿MMP-9呈显著负相关。
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