DIGITALIZATION IN CARDIOLOGY AND CARDIOREHABILITATION IN THE PERIOD OF COVID-19: THE ROLE OF ECG MARKERS IN CARDIOPROTECTION

Abstract

The aim of the work - to study the possibility of introducing ECG quantitative assessmentby its digital processing using the software in the real clinical practice to optimizetreatment in assessment of drugs’effectiveness at the stage of the patients’ rehabilitationin the time of COVID-19.Material and methods. The effectiveness of the drugs, used in rehabilitation, was analyzedaccording to the methodology of our previous study, 78 patients were diagnosed withacute Q-myocardial infarction in comparison with 46 patients who had stable angina IIfunctional class.Results. Tivortin and Tivorel increase Δ%RR-SDNN, which is associated with a reductionof the risk of adverse events and activation of the parasympathetic contour, Tivortinoptimizes ST-slope and accelerates transient depression of the ST-segment that reducesthe risk of death from cardiovascular disease and increases the antiarrhythmic effect,and also, the addition of "Tivortin" and "Tivorel" reduces the dispersion of the QTinterval, which indicates an anti-ischemic effect. An increasе of Δ%RR-SDNN index ishigher for bisoprolol than for amiodarone and indicates a positive effect, as a decreaseof this indicator is a risk factor for overall and cardiac mortality; amiodarone stimulatesthe activation of the parasympathetic contour; both drugs reduce the dispersion of QTinterval, which indicated anti-ischemic effect; amiodarone less efficiently affects ST-slopethan bisoprolol, but the effect of these drugs is associated with a reduction of adverseevents.Conclusion. The effectiveness of the assessment of the metabolic therapy at the stage ofrehabilitation of patients with cardiac pathology using the drugs "Tivortin", "Tivorel" incomparison with amiodarone and bisoprolol has been proved. Rehabilitation during theconstellation of acute myocardial infarction and COVID-19 is complicated by a decreaseof the number of admitted patients, more complicated course of the disease duringconstellation, non-urgent coronary interventions, a large number of complications, and aslowdown in rehabilitation measures.