Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.1
А.А. Antoniv
Purpose - to establish clinical peculiarities of the clinical course of the liver nonalcoholic steatosis (NALS) and steatohepatitis (NASH) at comorbidity with chronickidney disease (CKD) (chronic pyelonephritis) I-III stage.Material and methods. We have examined 444 patients: 84 patients with non-alcoholicadipose liver disease (NAALD) with obesity I degree (I group), containing 2 subgroups -32 patients with NALS and 52 patients with NASH; 270 NAALD patients with comorbidobesity I degree and CKD I-III stages (group 2), including 110 patients with NALS and160 patients with NASH. The control group consisted of 90 patients with CKD I-III stagewith normal body weight.Results. Clinical peculiarities of the liver non-alcoholic steatosis at comorbidity withCKD are a significant prevalence, in comparison with the clinical course without kidneypathology, of the frequency of manifestation of astheno-vegetative (70,9% to 40,6%),dyspeptic (33,6% to 18,8%), cholestatic (30,9% to 15,6%) syndromes, hepatomegaly(97,3% - 71,8%), predominance of steatosis II and III degree (47,2% and 31,8% to 25,0% and 15, 6% at NALS without kidney pathology). High frequency of asthenovegetative(98,1% to 61,5%) syndrome, dyspepsia (79,4% to 59,6%), discomfort in the rightsubcostal area (84,4% to 32,7%), cholestasis (37,5% to 17,3%), hepatomegaly (100,0%to 86,5%), prevalence of steatosis II and III degree (58,1% and 26,3% to 32,7% and11,5% at NASH without kidney pathology) is peculiar for non-alcoholic steatohepatitisclinical course at comorbidity with CKD as compared to the course without kidneypathology.Conclusions. Thus, the clinical course of nonalcoholic steatosis and steatohepatitis atcomorbidity with obesity and chronic kidney disease (CKD) is characterized by higherfrequency and intensity of the clinical and biochemical syndromes.
{"title":"PECULIARITIES OF THE CLINICAL COURSE OF NON-ALCOHOLIC STEATOHEPATITIS AND STEATOSIS OF THE LIVER AT COMORBID WITH CHRONIC KIDNEY DISEASE I-III STAGE","authors":"А.А. Antoniv","doi":"10.24061/1727-4338.XX.1.75.2021.1","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.1","url":null,"abstract":"Purpose - to establish clinical peculiarities of the clinical course of the liver nonalcoholic steatosis (NALS) and steatohepatitis (NASH) at comorbidity with chronickidney disease (CKD) (chronic pyelonephritis) I-III stage.Material and methods. We have examined 444 patients: 84 patients with non-alcoholicadipose liver disease (NAALD) with obesity I degree (I group), containing 2 subgroups -32 patients with NALS and 52 patients with NASH; 270 NAALD patients with comorbidobesity I degree and CKD I-III stages (group 2), including 110 patients with NALS and160 patients with NASH. The control group consisted of 90 patients with CKD I-III stagewith normal body weight.Results. Clinical peculiarities of the liver non-alcoholic steatosis at comorbidity withCKD are a significant prevalence, in comparison with the clinical course without kidneypathology, of the frequency of manifestation of astheno-vegetative (70,9% to 40,6%),dyspeptic (33,6% to 18,8%), cholestatic (30,9% to 15,6%) syndromes, hepatomegaly(97,3% - 71,8%), predominance of steatosis II and III degree (47,2% and 31,8% to 25,0% and 15, 6% at NALS without kidney pathology). High frequency of asthenovegetative(98,1% to 61,5%) syndrome, dyspepsia (79,4% to 59,6%), discomfort in the rightsubcostal area (84,4% to 32,7%), cholestasis (37,5% to 17,3%), hepatomegaly (100,0%to 86,5%), prevalence of steatosis II and III degree (58,1% and 26,3% to 32,7% and11,5% at NASH without kidney pathology) is peculiar for non-alcoholic steatohepatitisclinical course at comorbidity with CKD as compared to the course without kidneypathology.Conclusions. Thus, the clinical course of nonalcoholic steatosis and steatohepatitis atcomorbidity with obesity and chronic kidney disease (CKD) is characterized by higherfrequency and intensity of the clinical and biochemical syndromes.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77636931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.3
O. Hryniuk, I. Davydenko, O. Khukhlina, A. Antoniv, V. S. Haidychuk
Objective - to study the histochemical and histological features of the liver and lungtissues in patients with non-alcoholic steatohepatitis (NASH) and obesity under conditionof a comorbid course with chronic obstructive pulmonary disease (COPD).Material and methods. The autopsy material of 27 cases with NASH, including 13 casesof NASH and obesity of I degree (group 1), 14 cases of NASH, obesity of I degree withcomorbid COPD of II-III stage (group 2) was used. The groups of comparison includedautopsy material of 12 patients with isolated COPD of II-III stage (Group 3), as wellas 11 practically healthy persons (PHP), their main causes of death were polytraumaor traumatic brain injury or sudden coronary death. The groups were randomizedaccording to age, sex, degree of obesity. The average age of patients was (59,3 ± 3,21)years.Results. The volume of the connective tissue (CT) in the liver parenchyma in the 2nd groupwas in 1,9 times higher than in the 1st group (p<0,05), the specific volume of collagenfibers in 1,4 times, the optical density of collagen fibers by 1,2 times (p<0,05). In the 2ndgroup, the maximum damage to the respiratory parts of the lungs (RPL) was establishedin terms of percentage of filling of the RPL spaces with desquamated cells (in 9.4 times incomparison with PHP, by 1,3 times compared to the indicator in the 3rd group); specificvolume growth of the blood vessels in the peribronchial CT by 1,4 times (p<0,05). Thephenomena of venous thrombosis are most pronounced both in the peribronchial CT(they exceed the indicator in the 3rd group by 1,2 times) and respiratory parts of the lungs(by 2,4 times) (p<0,05). Patients of the 2nd group had the highest values of the specificvolume of CT in the lungs among all groups under study (19,8 ± 0,37 (p <0,05)).Conclusions. The comorbidity of COPD in patients with NASH and obesity contributedto the higher degree of activation of the connective tissue components in the liverparenchyma in comparison with the NASH indicators against a background of obesitywithout COPD, with an increase in the volume of the connective tissue (in 1,9 times,p<0,05), specific volume collagen fibers (by 1,4 times, p<0,05), optical density ofcollagen fibers coloring (in 1,2 times, p<0,05).
{"title":"PATHOMORPHOLOGY OF FIBROSING PROCESSES IN THE LIVER AND LUNGS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS AND OBESITY AT COMORBIDITY WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE","authors":"O. Hryniuk, I. Davydenko, O. Khukhlina, A. Antoniv, V. S. Haidychuk","doi":"10.24061/1727-4338.XX.1.75.2021.3","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.3","url":null,"abstract":"Objective - to study the histochemical and histological features of the liver and lungtissues in patients with non-alcoholic steatohepatitis (NASH) and obesity under conditionof a comorbid course with chronic obstructive pulmonary disease (COPD).Material and methods. The autopsy material of 27 cases with NASH, including 13 casesof NASH and obesity of I degree (group 1), 14 cases of NASH, obesity of I degree withcomorbid COPD of II-III stage (group 2) was used. The groups of comparison includedautopsy material of 12 patients with isolated COPD of II-III stage (Group 3), as wellas 11 practically healthy persons (PHP), their main causes of death were polytraumaor traumatic brain injury or sudden coronary death. The groups were randomizedaccording to age, sex, degree of obesity. The average age of patients was (59,3 ± 3,21)years.Results. The volume of the connective tissue (CT) in the liver parenchyma in the 2nd groupwas in 1,9 times higher than in the 1st group (p<0,05), the specific volume of collagenfibers in 1,4 times, the optical density of collagen fibers by 1,2 times (p<0,05). In the 2ndgroup, the maximum damage to the respiratory parts of the lungs (RPL) was establishedin terms of percentage of filling of the RPL spaces with desquamated cells (in 9.4 times incomparison with PHP, by 1,3 times compared to the indicator in the 3rd group); specificvolume growth of the blood vessels in the peribronchial CT by 1,4 times (p<0,05). Thephenomena of venous thrombosis are most pronounced both in the peribronchial CT(they exceed the indicator in the 3rd group by 1,2 times) and respiratory parts of the lungs(by 2,4 times) (p<0,05). Patients of the 2nd group had the highest values of the specificvolume of CT in the lungs among all groups under study (19,8 ± 0,37 (p <0,05)).Conclusions. The comorbidity of COPD in patients with NASH and obesity contributedto the higher degree of activation of the connective tissue components in the liverparenchyma in comparison with the NASH indicators against a background of obesitywithout COPD, with an increase in the volume of the connective tissue (in 1,9 times,p<0,05), specific volume collagen fibers (by 1,4 times, p<0,05), optical density ofcollagen fibers coloring (in 1,2 times, p<0,05).","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88179130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.15
T. Gargula
The introduction of distance learning in higher educational medical estalishments underconditions of pandemia has led to a reorganization of the educational process usingnew teaching methods, information and communication technologies (online platforms,video communication programs). In the system of training a qualified physician, clinicalanatomy and operative surgery occupy a leading place, as it develops clinical thinking,stimulates teamwork and is the basis for further study of surgery.The aim of the article - to highlight the advantages and disadvantages of teachingclinical anatomy and operative surgery to foreign students in terms of distance learningand ways to improve them.Conclusions. The study of clinical anatomy and operative surgery by foreign studentsin the context of distance learning has a number of advantages and disadvantagescompared to the traditional form. The use of the online platform Moodle (with studymaterials) and the Microsoft Teams service made it possible to conduct video lecturesand seminars online using interactive teaching methods that promote the motivationincrease and independence of foreign students. "Virtual" operational interventions usingan interactive method is a business game which allows not only to study the stages ofoperations but also to consolidate the algorithm of actions in different circumstances. Theuse of virtual and augmented reality technologies in the educational process becomes theclinical anatomy mastering better, makes it possible to improve its surgical component,which is especially important in the absence of the possibility of training operations.
{"title":"TEACHING OF CLINICAL ANATOMY AND OPERATIVE SURGERY TO FOREIGN STUDENTS IN REMOTE CONDITIONS: ADVANTAGES AND DISADVANTAGES","authors":"T. Gargula","doi":"10.24061/1727-4338.XX.1.75.2021.15","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.15","url":null,"abstract":"The introduction of distance learning in higher educational medical estalishments underconditions of pandemia has led to a reorganization of the educational process usingnew teaching methods, information and communication technologies (online platforms,video communication programs). In the system of training a qualified physician, clinicalanatomy and operative surgery occupy a leading place, as it develops clinical thinking,stimulates teamwork and is the basis for further study of surgery.The aim of the article - to highlight the advantages and disadvantages of teachingclinical anatomy and operative surgery to foreign students in terms of distance learningand ways to improve them.Conclusions. The study of clinical anatomy and operative surgery by foreign studentsin the context of distance learning has a number of advantages and disadvantagescompared to the traditional form. The use of the online platform Moodle (with studymaterials) and the Microsoft Teams service made it possible to conduct video lecturesand seminars online using interactive teaching methods that promote the motivationincrease and independence of foreign students. \"Virtual\" operational interventions usingan interactive method is a business game which allows not only to study the stages ofoperations but also to consolidate the algorithm of actions in different circumstances. Theuse of virtual and augmented reality technologies in the educational process becomes theclinical anatomy mastering better, makes it possible to improve its surgical component,which is especially important in the absence of the possibility of training operations.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"49 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77803662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.5
L. A. Ivanova, I. Horbatiuk, I. Horbatiuk, I. Balaniuk, A. O. Shkilnyuk
The aim of the study - to study the diagnostic significance of clinical and laboratoryparameters in the verification of acute non-streptococcal tonsillopharyngitis in childrenin order to determine rational treatment tactics.Material and methods. To achieve this aim, two clinical groups were formed. The first (I,main) group consisted of 66 patients with acute tonsillopharyngitis of non-streptococcaletiology, as evidenced by the negative result of bacterial examination of the lavage ofthe pharynx and posterior pharyngeal wall. The second (II) clinical group included 32children diagnosed with "streptococcal acute tonsillopharyngitis".Results. The total score on the McIsaac scale, which did not exceed 2 points, wasregistered in 15.2 ± 4.4% of group I patients and 6.2 ± 4.2% of patients in the comparisongroup. The sensitivity of the method was 15.2%, specificity – 93.7%, positive and negativepredicted value – 83.3% and 34.8%, respectively, with odds ratio – 2.6 [95% CI: 0.5-13,0]. The average content of leukocytes in the blood less than 8.9 × 109/l was registeredin 57.6% of patients of group I and 48.8% of representatives of the second (P˃0.05). Thesensitivity of this laboratory test in the detection of non-streptococcal tonsillopharyngitiswas 57.6%, specificity – 55.6%, predicted value of a positive result – 54.1%, predictedvalue of a negative result – 59.1%. The relative risk of non-streptococcal etiology of ATPwhen registering a patient with less than 8.9 × 109/l of peripheral blood leukocytes was1.7 (95% CI 0.9-2.9), the absolute risk – 0.1 with odds ratio of 1.7 (95% CI 0.9-2.9).Conclusions. The proposed clinical scales and some paraclinical parameters haveinsufficient diagnostic value, so they cannot be used independently for early verificationof non-streptococcal etiology of tonsillopharyngitis in children.
本研究旨在探讨临床及实验室参数在小儿急性非链球菌性扁桃体咽炎诊断中的诊断意义，以确定合理的治疗策略。材料和方法。为了达到这个目的，我们成立了两个临床小组。第一组(主要)为66例非链球菌性急性扁桃体咽炎患者，咽灌洗及咽后壁细菌检查阴性。第二(II)临床组包括32例诊断为“链球菌急性扁桃体咽炎”的儿童。McIsaac量表总分不超过2分，I组15.2±4.4%，对照组为6.2±4.2%。该方法的敏感性为15.2%，特异性为93.7%，阳性预测值和阴性预测值分别为83.3%和34.8%，优势比为2.6 [95% CI: 0.5 ~ 13,0]。第一组患者血液白细胞平均含量低于8.9 × 109/l的比例为57.6%，第二组为48.8% (P > 0.05)。该实验室检测非链球菌性扁桃体咽炎的敏感性为57.6%，特异性为55.6%，阳性预测值为54.1%，阴性预测值为59.1%。当登记的患者外周血白细胞低于8.9 × 109/l时，atp非链球菌病因的相对风险为1.7 (95% CI 0.9-2.9)，绝对风险为- 0.1，优势比为1.7 (95% CI 0.9-2.9)。所提出的临床量表及部分临床旁参数的诊断价值不足，不能独立用于儿童扁桃体咽炎非链球菌病原学的早期验证。
{"title":"DIAGNOSTIC SIGNIFICANCE OF CLINICAL AND LABORATORY INDICES IN VERIFICATION OF ACUTE NON-STREPTOCOCCAL TONSYLOPHARYNGITIS IN CHILDREN","authors":"L. A. Ivanova, I. Horbatiuk, I. Horbatiuk, I. Balaniuk, A. O. Shkilnyuk","doi":"10.24061/1727-4338.XX.1.75.2021.5","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.5","url":null,"abstract":"The aim of the study - to study the diagnostic significance of clinical and laboratoryparameters in the verification of acute non-streptococcal tonsillopharyngitis in childrenin order to determine rational treatment tactics.Material and methods. To achieve this aim, two clinical groups were formed. The first (I,main) group consisted of 66 patients with acute tonsillopharyngitis of non-streptococcaletiology, as evidenced by the negative result of bacterial examination of the lavage ofthe pharynx and posterior pharyngeal wall. The second (II) clinical group included 32children diagnosed with \"streptococcal acute tonsillopharyngitis\".Results. The total score on the McIsaac scale, which did not exceed 2 points, wasregistered in 15.2 ± 4.4% of group I patients and 6.2 ± 4.2% of patients in the comparisongroup. The sensitivity of the method was 15.2%, specificity – 93.7%, positive and negativepredicted value – 83.3% and 34.8%, respectively, with odds ratio – 2.6 [95% CI: 0.5-13,0]. The average content of leukocytes in the blood less than 8.9 × 109/l was registeredin 57.6% of patients of group I and 48.8% of representatives of the second (P˃0.05). Thesensitivity of this laboratory test in the detection of non-streptococcal tonsillopharyngitiswas 57.6%, specificity – 55.6%, predicted value of a positive result – 54.1%, predictedvalue of a negative result – 59.1%. The relative risk of non-streptococcal etiology of ATPwhen registering a patient with less than 8.9 × 109/l of peripheral blood leukocytes was1.7 (95% CI 0.9-2.9), the absolute risk – 0.1 with odds ratio of 1.7 (95% CI 0.9-2.9).Conclusions. The proposed clinical scales and some paraclinical parameters haveinsufficient diagnostic value, so they cannot be used independently for early verificationof non-streptococcal etiology of tonsillopharyngitis in children.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76521529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.8
O. Koloskova, Т. Bilous, О.P. Korotun, F. Herman, V. Bilous, S. I. Seliverstov
Objectives - to analyze the activity of the inflammatory process in the airways of childrenwith bronchial asthma depending on different onset of the disease.Material and methods. Keeping to the principles of bioethics a comprehensiveretrospective examination of 319 children suffering from BA was performed. In 257children (clinical group I) bronchial asthma developed against a background of chronicobstructive bronchitis. The second clinical group included 43 children, in whom asthmadebuted after community-acquired pneumonia. The third (III) clinical group consistedof 19 children in whom asthma was first verified after inpatient treatment for asthmaticstatus.Results. According to the severity of bronchial asthma, it was found that the representativesof the III clinical group, compared with other patients, significantly more often had a severecourse of the disease. For patients of the I clinical group in the debut it is characterizedby increased eosinophils and decreased neutrophil counts in sputum, for patients ofgroup II - increased eosinophils and epitheliocytes, but a decrease in lymphocytes, andfor children of clinical group III - low eosinophils sputum with a simultaneous increasein neutrophils. In particular, a statistically significant increase in the content of VEGF,a decrease in the content of cationic proteins, MMP-9, and interleukins-6, and -13 inthe sputum indicates the predominance of neoangiogenesis in children of clinical groupIII. Instead, in the representatives of the II clinical group the remodeling processes weremainly caused by the inflammatory process with the release of intracellular eosinophiliccationic proteins.Conclusion. These data indicate the discrete nature of the type and severity of theinflammatory process of the respiratory tract in the dynamics of observation in childrenof clinical comparison groups, which suggests the presence of certain phenotypicdifferences due to the alternative onset of the disease, which in its turn was determinedby different triggers. Such deviations of the inflammatory process indicate that patientswith asthma require a personalized approach to differentiated diagnostic monitoring andtargeted anti-inflammatory treatment, taking into account the peculiarities of the onsetof the disease.
{"title":"BIOMARKERS OF INFLAMMATION AT BRONCHIAL ASTHMA IN CHILDREN WITH ALTERNATIVE DEBUT OF THE DISEASE","authors":"O. Koloskova, Т. Bilous, О.P. Korotun, F. Herman, V. Bilous, S. I. Seliverstov","doi":"10.24061/1727-4338.XX.1.75.2021.8","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.8","url":null,"abstract":"Objectives - to analyze the activity of the inflammatory process in the airways of childrenwith bronchial asthma depending on different onset of the disease.Material and methods. Keeping to the principles of bioethics a comprehensiveretrospective examination of 319 children suffering from BA was performed. In 257children (clinical group I) bronchial asthma developed against a background of chronicobstructive bronchitis. The second clinical group included 43 children, in whom asthmadebuted after community-acquired pneumonia. The third (III) clinical group consistedof 19 children in whom asthma was first verified after inpatient treatment for asthmaticstatus.Results. According to the severity of bronchial asthma, it was found that the representativesof the III clinical group, compared with other patients, significantly more often had a severecourse of the disease. For patients of the I clinical group in the debut it is characterizedby increased eosinophils and decreased neutrophil counts in sputum, for patients ofgroup II - increased eosinophils and epitheliocytes, but a decrease in lymphocytes, andfor children of clinical group III - low eosinophils sputum with a simultaneous increasein neutrophils. In particular, a statistically significant increase in the content of VEGF,a decrease in the content of cationic proteins, MMP-9, and interleukins-6, and -13 inthe sputum indicates the predominance of neoangiogenesis in children of clinical groupIII. Instead, in the representatives of the II clinical group the remodeling processes weremainly caused by the inflammatory process with the release of intracellular eosinophiliccationic proteins.Conclusion. These data indicate the discrete nature of the type and severity of theinflammatory process of the respiratory tract in the dynamics of observation in childrenof clinical comparison groups, which suggests the presence of certain phenotypicdifferences due to the alternative onset of the disease, which in its turn was determinedby different triggers. Such deviations of the inflammatory process indicate that patientswith asthma require a personalized approach to differentiated diagnostic monitoring andtargeted anti-inflammatory treatment, taking into account the peculiarities of the onsetof the disease.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80433367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.6
L. A. Ivanova, M. Haras, L. Romanchuk, L. Huk
The aim of the research - to analyze the epidemiological and clinical peculiarities ofcoronavirus disease COVID-19 in infants compared to the older age group.Materials and methods. 188 inpatient cards of children who were hospitalized in theinfectious diseases departments of Chernivtsi Regional Children's Clinical Hospitalwith COVID-19 infection were analyzed, in particular, 63 children under 1 year of age(1st group) and 125 children aged 1 year and older (2nd group, comparison group).A complex of anamnestic, epidemiological and clinical characteristics of COVID-19infection was determined in hospitalized children.Results. During the analysis of the data it was found that the epidemiologicalsignificance was related to family contacts, unidentified non-family sources of infectionwere observed in a quarter of infants (25,4%) and 39,2% of children of group II (p 0,05), 30,2% infants had rhinorrhea (16,8% in the 2nd group,p<0,05), while in the comparison group the symptoms from the lower respiratory tractdominated, in particular, cough was significant more often observed (59,2% vs. 26,9%in the 1st group, p<0,05). Lesions of the lower respiratory tract with the development ofpneumonia were significant more common in 32,0% of children in 2nd group and only in8,0% of infants (p<0,05).Conclusions. Epidemiologically, the start of COVID-19 pandemic in Chernivtsi regionwith restrictive quarantine measures was characterized by a predominance of familialinfection and a significant proportion of unexplained extracurricular sources of infectionin children. In most infants with coronavirus disease caused by the new SARS-CoV-2coronavirus, respiratory symptoms were dominated by signs of upper respiratory tractinvolvement.
{"title":"CLINICAL AND EPIDEMIOLOGICAL PECULIARITIES IF COVID-19 INFECTION IN INFANTS","authors":"L. A. Ivanova, M. Haras, L. Romanchuk, L. Huk","doi":"10.24061/1727-4338.XX.1.75.2021.6","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.6","url":null,"abstract":"The aim of the research - to analyze the epidemiological and clinical peculiarities ofcoronavirus disease COVID-19 in infants compared to the older age group.Materials and methods. 188 inpatient cards of children who were hospitalized in theinfectious diseases departments of Chernivtsi Regional Children's Clinical Hospitalwith COVID-19 infection were analyzed, in particular, 63 children under 1 year of age(1st group) and 125 children aged 1 year and older (2nd group, comparison group).A complex of anamnestic, epidemiological and clinical characteristics of COVID-19infection was determined in hospitalized children.Results. During the analysis of the data it was found that the epidemiologicalsignificance was related to family contacts, unidentified non-family sources of infectionwere observed in a quarter of infants (25,4%) and 39,2% of children of group II (p 0,05), 30,2% infants had rhinorrhea (16,8% in the 2nd group,p<0,05), while in the comparison group the symptoms from the lower respiratory tractdominated, in particular, cough was significant more often observed (59,2% vs. 26,9%in the 1st group, p<0,05). Lesions of the lower respiratory tract with the development ofpneumonia were significant more common in 32,0% of children in 2nd group and only in8,0% of infants (p<0,05).Conclusions. Epidemiologically, the start of COVID-19 pandemic in Chernivtsi regionwith restrictive quarantine measures was characterized by a predominance of familialinfection and a significant proportion of unexplained extracurricular sources of infectionin children. In most infants with coronavirus disease caused by the new SARS-CoV-2coronavirus, respiratory symptoms were dominated by signs of upper respiratory tractinvolvement.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75105050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.12
Y. Karvatska, O. Denysenko
The аim of research – the clinical results of complex therapy in patients with acne vulgaris- residents of the iodine deficiency region should be determined and analyzed consideringthe state of their pituitary-thyroid system, intestinal microbiota and immunologicalparameters.Material and methods. The study involved 109 patients with moderate to severe acnevulgaris, who are the residents of Chernivtsi region - a region with natural iodinedeficiency. Examination of the patients revealed changes in the pituitary-thyroid system,immunological parameters and intestinal biocenosis, which corresponded to the severityof dermatosis. During treatment, patients were divided into 3 groups: I comparative - 36people who received conventional acne therapies and medicines to normalize thyroidhomeostasis; group II comparative - 36 patients who were additionally prescribedprobiotics, and ІІІ (main) - 37 persons who received complex treatment with the additionaladministration of probiotics and immunotropic drug. The effectiveness of treatment ofpatients was evaluated by their earliest and long-term clinical results using statisticalanalysis methods.Results. It has been established that complex therapy of patients with moderate and severeacne vulgaris - residents of the iodine deficiency region with the administration alongsidewith the conventional acne therapy of medicines that normalize detected changes in thepituitary-thyroid system, immunotropic drug glucosaminylmuramyl dipeptide (licopid))and probiotic (lacium) reliably reduces (p <0.01) in comparison with conventional acnetherapy or conventional acne therapy with additional probiotics administration the termsof regress of acute inflammatory elements of acne with the achievement of the state ofclinical remission of dermatosis, (respectively: by 1,54 and 1,41 times). The frequency ofexacerbations acne process of patients with moderate and severe acne vulgaris duringthe year were also reduced (respectively: 1.59 and 1.26 times) relatively to patients in thecomparison groups.Conclusion. The complex therapy of patients with moderate to severe acne - residentsof the iodine deficiency region with administration of medicines to normalize thyroidhomeostasis, immunotropic drug glucosaminylmuramyl dipeptide (licopid) and probiotic(lacium) reliable improves the earliest and long-term clinical results of their treatment incomparison with conventional treatment or treatment using only the probiotic additionalprescription.
{"title":"CLINICAL RESULTS OF COMPLEX THERAPY ОF PATIENTS WITH ACNE - RESIDENTS OF IODINE DEFICIENCY REGION","authors":"Y. Karvatska, O. Denysenko","doi":"10.24061/1727-4338.XX.1.75.2021.12","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.12","url":null,"abstract":"The аim of research – the clinical results of complex therapy in patients with acne vulgaris- residents of the iodine deficiency region should be determined and analyzed consideringthe state of their pituitary-thyroid system, intestinal microbiota and immunologicalparameters.Material and methods. The study involved 109 patients with moderate to severe acnevulgaris, who are the residents of Chernivtsi region - a region with natural iodinedeficiency. Examination of the patients revealed changes in the pituitary-thyroid system,immunological parameters and intestinal biocenosis, which corresponded to the severityof dermatosis. During treatment, patients were divided into 3 groups: I comparative - 36people who received conventional acne therapies and medicines to normalize thyroidhomeostasis; group II comparative - 36 patients who were additionally prescribedprobiotics, and ІІІ (main) - 37 persons who received complex treatment with the additionaladministration of probiotics and immunotropic drug. The effectiveness of treatment ofpatients was evaluated by their earliest and long-term clinical results using statisticalanalysis methods.Results. It has been established that complex therapy of patients with moderate and severeacne vulgaris - residents of the iodine deficiency region with the administration alongsidewith the conventional acne therapy of medicines that normalize detected changes in thepituitary-thyroid system, immunotropic drug glucosaminylmuramyl dipeptide (licopid))and probiotic (lacium) reliably reduces (p <0.01) in comparison with conventional acnetherapy or conventional acne therapy with additional probiotics administration the termsof regress of acute inflammatory elements of acne with the achievement of the state ofclinical remission of dermatosis, (respectively: by 1,54 and 1,41 times). The frequency ofexacerbations acne process of patients with moderate and severe acne vulgaris duringthe year were also reduced (respectively: 1.59 and 1.26 times) relatively to patients in thecomparison groups.Conclusion. The complex therapy of patients with moderate to severe acne - residentsof the iodine deficiency region with administration of medicines to normalize thyroidhomeostasis, immunotropic drug glucosaminylmuramyl dipeptide (licopid) and probiotic(lacium) reliable improves the earliest and long-term clinical results of their treatment incomparison with conventional treatment or treatment using only the probiotic additionalprescription.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91417467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.7
О. Koloskova, Т. Bilous, M. Garas, I. Horbatiuk, L. Ivanova, L. Romanchuk, R. Tkachuk
Purpose - to study particular properties of the course of the infection among hospitalizedchildren depending on the nature of their treatment provided in pre-hospitalizationperiod in order to improve the results of treatment of children with COVID-19.Material and methods. In a random sample 263 children with COVID-19, admittedto the Department of infectious diseases of the Regional Children's Clinical Hospitalof Chernivtsi, have been examined. The first clinical group includes 68 patients thatreceived antiviral treatment as a part of symptomatic therapy (average age 6,5 ± 0,74years, male ratio 54,4%), and the comparison group - 195 children that did not receiveantiviral activity treatment (average age 6,4 ± 0,41 years, male ratio 50,8%).Results. Most patients with COVID-19 presented signs of moderate to severe medicalstate when admitted to hospital. Patients that did not receive any antiviral therapy in thepre-hospitalization period showed delayed body temperature normalization response (onaverage on the 5th day of the treatment) and, starting from the day 10 of hospitalization,experienced elevated body temperature again caused by infectious and inflammatoryprocess as a result of COVID-19 complications. Changes concerning hemostasisinclude an increase of absolute count of platelets in the blood, reduction in plasmarecalcification time and increase of plasma D-dimer levels (p <0,05). Administration ofantiviral therapy to the children with Covid-19 in the outpatient setting is accompaniedwith absolute risk reduction of a positive PCR test 25% on the 14th day of the disease.Conclusions. Therefore, administration of antiviral therapy to the children with Covid-19in the outpatient setting is characterized with slightly faster temperature normalizationresponse, better clinical signs, virus elimination (minimization of the possibility of apositive PCR test 25%), as well as less excessive hypercoagulable disorder.
{"title":"EXPEDIENCY OF ANTIVIRAL THERAPY AT CHILL IN CHILDREN DURING PANDEMIA COVID-19","authors":"О. Koloskova, Т. Bilous, M. Garas, I. Horbatiuk, L. Ivanova, L. Romanchuk, R. Tkachuk","doi":"10.24061/1727-4338.XX.1.75.2021.7","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.7","url":null,"abstract":"Purpose - to study particular properties of the course of the infection among hospitalizedchildren depending on the nature of their treatment provided in pre-hospitalizationperiod in order to improve the results of treatment of children with COVID-19.Material and methods. In a random sample 263 children with COVID-19, admittedto the Department of infectious diseases of the Regional Children's Clinical Hospitalof Chernivtsi, have been examined. The first clinical group includes 68 patients thatreceived antiviral treatment as a part of symptomatic therapy (average age 6,5 ± 0,74years, male ratio 54,4%), and the comparison group - 195 children that did not receiveantiviral activity treatment (average age 6,4 ± 0,41 years, male ratio 50,8%).Results. Most patients with COVID-19 presented signs of moderate to severe medicalstate when admitted to hospital. Patients that did not receive any antiviral therapy in thepre-hospitalization period showed delayed body temperature normalization response (onaverage on the 5th day of the treatment) and, starting from the day 10 of hospitalization,experienced elevated body temperature again caused by infectious and inflammatoryprocess as a result of COVID-19 complications. Changes concerning hemostasisinclude an increase of absolute count of platelets in the blood, reduction in plasmarecalcification time and increase of plasma D-dimer levels (p <0,05). Administration ofantiviral therapy to the children with Covid-19 in the outpatient setting is accompaniedwith absolute risk reduction of a positive PCR test 25% on the 14th day of the disease.Conclusions. Therefore, administration of antiviral therapy to the children with Covid-19in the outpatient setting is characterized with slightly faster temperature normalizationresponse, better clinical signs, virus elimination (minimization of the possibility of apositive PCR test 25%), as well as less excessive hypercoagulable disorder.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81194506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.9
L. Kolyubakina, O. V. Vlasova, N. Kretsu, Е.Z. Trekush
A lot of data concerning the epidemiological features of the pathogen, clinical andparaclinical characteristics of the disease, principles of diagnosis and approaches tothe treatment have been published in the scientific literature during the year of pandemiacaused by SARS-CoV-2. But still there are many unresolved issues regarding theepidemiological and clinical characteristics of this coronavirus infection in newborns.Purpose – to conduct observational study of the peculiarities of SARS-CoV-2 coronavirusinfection in newborns treated during 2020 on the basis of RCNE "Chernivtsi RegionalChildren's Clinical Hospital", Chernivtsi.Material and methods. Analysis of medical records of 12 inpatient newborns wasconducted retrospectively to achieve the goal of the study. Inclusion criteria: age 0-28days of life, confirmed by positive test of polymerase chain reaction (PCR) for SARSCoV-2 coronavirus infection of a nasopharyngeal smear. The average age of childrenat the time of admission was 13.6 ± 2.1 days, every third newborn child (33.3%) wasadmitted before the age of 10 days old. The portion of rural residents was 66.6%, girls(75%) predominated among children who fell ill.Results. It has been revealed that in most cases the contact of newborns with COVID-19patients was confirmed. Mostly children were admitted from home on average onthe second day after the onset of the disease, predominantly with the typical clinicalsymptoms of acute respiratory viral infection, at the onset of the disease gastrointestinalmanifestations prevailed in only two of patients. The course of the disease was favorable.Conclusions. The detected changes in the follow-up infants’ complete blood count requirefurther dynamic clinical and paraclinical observation.
{"title":"PECULIARITIES OF CORONAVIRUS INFECTION CLINICAL COURSE CAUSED BY SARS-COV-2 IN NEWBORNS","authors":"L. Kolyubakina, O. V. Vlasova, N. Kretsu, Е.Z. Trekush","doi":"10.24061/1727-4338.XX.1.75.2021.9","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.9","url":null,"abstract":"A lot of data concerning the epidemiological features of the pathogen, clinical andparaclinical characteristics of the disease, principles of diagnosis and approaches tothe treatment have been published in the scientific literature during the year of pandemiacaused by SARS-CoV-2. But still there are many unresolved issues regarding theepidemiological and clinical characteristics of this coronavirus infection in newborns.Purpose – to conduct observational study of the peculiarities of SARS-CoV-2 coronavirusinfection in newborns treated during 2020 on the basis of RCNE \"Chernivtsi RegionalChildren's Clinical Hospital\", Chernivtsi.Material and methods. Analysis of medical records of 12 inpatient newborns wasconducted retrospectively to achieve the goal of the study. Inclusion criteria: age 0-28days of life, confirmed by positive test of polymerase chain reaction (PCR) for SARSCoV-2 coronavirus infection of a nasopharyngeal smear. The average age of childrenat the time of admission was 13.6 ± 2.1 days, every third newborn child (33.3%) wasadmitted before the age of 10 days old. The portion of rural residents was 66.6%, girls(75%) predominated among children who fell ill.Results. It has been revealed that in most cases the contact of newborns with COVID-19patients was confirmed. Mostly children were admitted from home on average onthe second day after the onset of the disease, predominantly with the typical clinicalsymptoms of acute respiratory viral infection, at the onset of the disease gastrointestinalmanifestations prevailed in only two of patients. The course of the disease was favorable.Conclusions. The detected changes in the follow-up infants’ complete blood count requirefurther dynamic clinical and paraclinical observation.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82796255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.24061/1727-4338.XX.1.75.2021.11
І.А. Plesh, L. I. Gaidych
Aim - establish features of arterial and venous hemodynamics in patients with the 2ndstage of essential hypertension (EH) with various options of circadian structure of theblood pressure (BP).Material and methods. There were examined 52 patients with the 2nd stage of essentialhypertension (EH) with the average age of 54,8±2,12. All patients underwent daily BPmonitoring (DBPM) with the help of the hardware complex "Solvaig" (Ukraine) andangiotensiotonoreobarography according to the author's method that determined thevalues of the pressures of closing and opening the arteries and veins of the limb underthe medical cuff (as for checking BP).Results. According to the data of DBPM in “non-dippers” patients the average dailypulse blood pressure (APBP) was significantly higher in the night picker (NP), and theaverage dynamic blood pressure increased mainly during the night period.The values of the daily index in these groups “non-dippers” (ND) and NP are mainlycaused by the daily dynamics of the diastolic BP.There were detected 17(80.8%) patients of the ND group and 12 (92.3%) patients withNP rhythm that had a high level of venous closure pressure. Venous hypertension wasconfirmed according to the data of CVP by the classical method of Waldman.The proposed method of examination of patients with the 2nd stage of essentialhypertension makes it possible to detect arteriovenous hypertension and to determineit as a significant risk factor for the progression of EH and resistant to treatment form,pathogenetically justify complex AH-therapy using optimal doses of diuretics.Conclusion. Circadian variant - ND and NP "not dippers" has been revealed in mostpatients with the 2nd stage of EH (65.4%). Combined arteriovenous hypertension(AVH) was detected in 87% of thematic patients with daily ND and NP structure. Thediagnosed AVH in patients with the 2nd stage of EH is an additional risk factor for EHand requires a pathogenetically sound approach to AH-treatment with mandatory useof diuretics in optimal doses.
{"title":"SOME FEATURES OF ARTERIAL AND VENOUS HEMODYNAMICS IN PATIENTS WITH ESSENTIAL HYPERTENTION STAGE II WITH DIFFERENT VARIANTS OF THE BLOOD PRESSURE DAILY STRUCTURE","authors":"І.А. Plesh, L. I. Gaidych","doi":"10.24061/1727-4338.XX.1.75.2021.11","DOIUrl":"https://doi.org/10.24061/1727-4338.XX.1.75.2021.11","url":null,"abstract":"Aim - establish features of arterial and venous hemodynamics in patients with the 2ndstage of essential hypertension (EH) with various options of circadian structure of theblood pressure (BP).Material and methods. There were examined 52 patients with the 2nd stage of essentialhypertension (EH) with the average age of 54,8±2,12. All patients underwent daily BPmonitoring (DBPM) with the help of the hardware complex \"Solvaig\" (Ukraine) andangiotensiotonoreobarography according to the author's method that determined thevalues of the pressures of closing and opening the arteries and veins of the limb underthe medical cuff (as for checking BP).Results. According to the data of DBPM in “non-dippers” patients the average dailypulse blood pressure (APBP) was significantly higher in the night picker (NP), and theaverage dynamic blood pressure increased mainly during the night period.The values of the daily index in these groups “non-dippers” (ND) and NP are mainlycaused by the daily dynamics of the diastolic BP.There were detected 17(80.8%) patients of the ND group and 12 (92.3%) patients withNP rhythm that had a high level of venous closure pressure. Venous hypertension wasconfirmed according to the data of CVP by the classical method of Waldman.The proposed method of examination of patients with the 2nd stage of essentialhypertension makes it possible to detect arteriovenous hypertension and to determineit as a significant risk factor for the progression of EH and resistant to treatment form,pathogenetically justify complex AH-therapy using optimal doses of diuretics.Conclusion. Circadian variant - ND and NP \"not dippers\" has been revealed in mostpatients with the 2nd stage of EH (65.4%). Combined arteriovenous hypertension(AVH) was detected in 87% of thematic patients with daily ND and NP structure. Thediagnosed AVH in patients with the 2nd stage of EH is an additional risk factor for EHand requires a pathogenetically sound approach to AH-treatment with mandatory useof diuretics in optimal doses.","PeriodicalId":12291,"journal":{"name":"Experimental pathology","volume":"10 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74530749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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