POTENTIAL OF IMIDAZOLE-CONTAINING DERIVATIVES FOR PRACTICAL APPLICATION (Review)

Abstract

The imidazole ring is becoming a popular structural fragment in synthetic pharmaceuticals, being an ionizing and aromatic component, which activates pharmacokinetic properties. The imidazole cycle is present in many antiprototic, antifungal and antihypertensive drugs, antibiotics and others. These structures are effective against various strains of microorganisms. The imidazole block is contained in the anticancer drug mercaptopurine, which has an effect by interfering with the DNA activity in the treatment of leukemia. Purpose: to review imidazole derivatives with various types of physiological and/or other actions published in the scientific literature over the last twenty years. Objects of research: imidazole derivatives. Results.An imidazole fragment is contained in a large number of natural products and clinically active drug molecules. Most of the publications relate to the study of the therapeutic possibilities of new structures of the class of imidazole derivatives for medical use. However, the potential of imidazole-containing molecules is not limited only to BAS, their other properties are interesting, in particular such one as corrosion inhibition. Conclusion: The introduction of a highly active imidazole fragment into an organic molecule stimulated the appearance of notable achievements in the field of chemotherapeutic and antibacterial agents. The active synthetic search for highly active imidazole compounds continues not only in the field of biologically active compounds, but also as the potential anticorrosiveand other agents.