Hector Huerga Encabo, Laia Traveset, J. Argilaguet, A. Angulo, Estanislao Nistal-Villán, R. Jaiswal, C. Escalante, C. Gekas, A. Meyerhans, J. Aramburu, C. López-Rodríguez
{"title":"The transcription factor NFAT5 limits infection-induced type I interferon responses","authors":"Hector Huerga Encabo, Laia Traveset, J. Argilaguet, A. Angulo, Estanislao Nistal-Villán, R. Jaiswal, C. Escalante, C. Gekas, A. Meyerhans, J. Aramburu, C. López-Rodríguez","doi":"10.1084/jem.20190449","DOIUrl":null,"url":null,"abstract":"Huerga Encabo et al. show that NFAT5, previously characterized as a pro-inflammatory transcription factor, limits the IFN-I response to control antiviral defenses and preserve HSC quiescence. NFAT5 represses IFN-I and ISG expression through an evolutionarily conserved DNA element that prevents IRF3 recruitment to the IFNB1 enhanceosome.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"7 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190449","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
Huerga Encabo et al. show that NFAT5, previously characterized as a pro-inflammatory transcription factor, limits the IFN-I response to control antiviral defenses and preserve HSC quiescence. NFAT5 represses IFN-I and ISG expression through an evolutionarily conserved DNA element that prevents IRF3 recruitment to the IFNB1 enhanceosome.
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