Yifan Zhou, Yusra B Medik, B. Patel, D. Zamler, Sijie Chen, T. Chapman, Sarah Schneider, Rachel L. Babcock, Taylor T. Chrisikos, Laura M. Kahn, Allison M. Dyevoich, E. Park, Alexandria P. Cogdill, Daniel H Johnson, Sarah B. Johnson, K. Wani, D. Ledesma, C. Hudgens, Jingjing Wang, M. A. W. Khan, Aron Y Joon, W. Peng, Haiyan S. Li, R. Arora, Ximing Tang, M. G. Raso, Xuegong Zhang, W. Foo, M. Tetzlaff, G. Diehl, K. Clise-Dwyer, Elizabeth M Whitley, M. Gubin, J. Allison, P. Hwu, N. Ajami, A. Diab, J. Wargo, S. Watowich
{"title":"Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration","authors":"Yifan Zhou, Yusra B Medik, B. Patel, D. Zamler, Sijie Chen, T. Chapman, Sarah Schneider, Rachel L. Babcock, Taylor T. Chrisikos, Laura M. Kahn, Allison M. Dyevoich, E. Park, Alexandria P. Cogdill, Daniel H Johnson, Sarah B. Johnson, K. Wani, D. Ledesma, C. Hudgens, Jingjing Wang, M. A. W. Khan, Aron Y Joon, W. Peng, Haiyan S. Li, R. Arora, Ximing Tang, M. G. Raso, Xuegong Zhang, W. Foo, M. Tetzlaff, G. Diehl, K. Clise-Dwyer, Elizabeth M Whitley, M. Gubin, J. Allison, P. Hwu, N. Ajami, A. Diab, J. Wargo, S. Watowich","doi":"10.1158/1538-7445.am2022-5545","DOIUrl":null,"url":null,"abstract":"Zhou et al. establish murine models of anti-CTLA-4–mediated intestinal irAEs. These reveal common immune signatures and the importance of fecal microbiome dysbiosis as irAE-driving mechanisms, which enable preclinical therapeutic interventions. Key immune features are validated in a cohort of melanoma patients with ICB-associated intestinal irAEs.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1158/1538-7445.am2022-5545","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
Zhou et al. establish murine models of anti-CTLA-4–mediated intestinal irAEs. These reveal common immune signatures and the importance of fecal microbiome dysbiosis as irAE-driving mechanisms, which enable preclinical therapeutic interventions. Key immune features are validated in a cohort of melanoma patients with ICB-associated intestinal irAEs.
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