Evaluation of a dinotefuran-permethrin-pyriorixyfen insect repellent in dogs exposed to experimental infestations of sand flies (Lutzomyia longipalpis)

Abstract

Visceral leishmaniasis is a serious zoonosis, and has a high incidence in Brazil. The ubiquitous presence of sand flies is a major player in the high incidence of leishmaniasis in urban areas of Brazil. Prevention and control or canine leishmaniasis is important to decrease the incidence of the zoonosis. Control is done with topical use of products with antiparasitic, repellent and insecticide action. This study evaluated the repellent efficacy of line-on application of a topical permethrin-dinotefuran-pyriproxyfen formulation in dogs. Six dogs were treated with the product and six did not receive treatment. All dogs were sedated and exposed to sand flies of the species Lutzomyia longipalpis weekly for 28 days. The result showed that the product had an efficacy of 90.4% in repelling sand flies. There was statistical significance (p ≤ 0,05) difference in the number (mean) of live engorged sand fly females between the two groups in all evaluations. The product showed repellent efficacy against Lutzomyia longipalpis for 28 days.