S. Mukhopadhyay, E. Heinz, I. Porreca, K. Alasoo, Amy T. Y. Yeung, Huei-Ting Yang, T. Schwerd, J. Forbester, C. Hale, Chukwuma A. Agu, Yoon Ha Choi, Julia Rodrigues, M. Capitani, L. Jostins-Dean, D. Thomas, S. Travis, Daniel J. Gaffney, W. Skarnes, N. Thomson, H. Uhlig, G. Dougan, F. Powrie
{"title":"Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2","authors":"S. Mukhopadhyay, E. Heinz, I. Porreca, K. Alasoo, Amy T. Y. Yeung, Huei-Ting Yang, T. Schwerd, J. Forbester, C. Hale, Chukwuma A. Agu, Yoon Ha Choi, Julia Rodrigues, M. Capitani, L. Jostins-Dean, D. Thomas, S. Travis, Daniel J. Gaffney, W. Skarnes, N. Thomson, H. Uhlig, G. Dougan, F. Powrie","doi":"10.1084/jem.20180649","DOIUrl":null,"url":null,"abstract":"Cytokines and lipid mediators are key regulators of inflammation; but how they are mechanistically linked is poorly understood. Here, Mukhopadhyay et al. show a novel regulation between cytokine IL-10 and lipid mediator PGE2 that functionally connects them to intestinal inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"93 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"41","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20180649","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 41
Abstract
Cytokines and lipid mediators are key regulators of inflammation; but how they are mechanistically linked is poorly understood. Here, Mukhopadhyay et al. show a novel regulation between cytokine IL-10 and lipid mediator PGE2 that functionally connects them to intestinal inflammation.