Thyroidectomy induced hepatic toxicity and possible amelioration by Ginkgo biloba leaf extract

Ehab Tousson , Areej J.M. Alghabban , Heba Abou Harga
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引用次数: 11

Abstract

The liver is a major target organ for thyroid hormone action and marked changes occur in liver functions in the case of hypo- or hyperthyroidism. This studied aimed at inverstigating the biochemical and histopathological changes in the liver after thyroidectomy and the ameliorating role of Ginkgo biloba leaf extract (GLE). A total of 50 male albino rats were equally divided into five groups; 1st to 3rd groups were control, sham operated and GLE groups while 4th group was thyroidectomized rat group and 5th group was treated thyrodectomized rat with GLE. Serum T3 and T4 levels after 3 weeks of thyroidectomy was significantly decreased when compared with the control group, while TSH significantly increased when compared with the control group increased. Serum ALT, AST, ALP and GGT showed significant (P < 0.05) increase in thyroidectomized group when compared with control, sham operated and sham operated with GLE groups. On the one hand, treatment of thyroidectomized rats with GLE improved this increase in serum ALT, AST, ALP and GGT in thyroidectomized rat group. Liver sections of thyroidectomy group showed marked positive reaction and increase number of PCNA staining of hepatocyte nuclei. On the other hand, liver in treated of thyroidectomized rat with GLE group showed a marked reduction in the number of PCNA-positive nuclei when compared with sections in thyroidectomy group. Treatment of thyroidectomized rat with GLE improves the biochemical, histopathological and immunohistochemical alternations and the intensity of PCNA immunoreactive cells demonstrating the recovery of some injury.

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甲状腺切除术引起的肝毒性和银杏叶提取物可能的改善
肝脏是甲状腺激素作用的主要靶器官,在甲状腺功能减退或甲状腺功能亢进的情况下,肝功能会发生显著变化。本研究旨在探讨银杏叶提取物(Ginkgo biloba leaf extract, GLE)对甲状腺切除术后肝脏生化和组织病理学变化的改善作用。将50只雄性白化大鼠平均分为5组;第1 ~ 3组为对照组、假手术组和GLE组,第4组为去甲状腺大鼠组,第5组用GLE治疗去甲状腺大鼠。甲状腺切除术后3周血清T3、T4水平较对照组显著降低,TSH水平较对照组显著升高。血清ALT、AST、ALP、GGT差异均有统计学意义(P <甲状腺切除组与对照组、假手术组、假手术组与GLE组比较,均增高0.05)。一方面,GLE对去甲状腺大鼠的治疗改善了去甲状腺大鼠组血清ALT、AST、ALP和GGT的升高。甲状腺切除术组肝切片阳性反应明显,肝细胞核PCNA染色增多。另一方面,与甲状腺切除组相比,GLE组甲状腺切除大鼠肝脏中pcna阳性细胞核数量明显减少。GLE能改善甲状腺切除大鼠的生化、组织病理学和免疫组织化学变化,改善PCNA免疫反应细胞强度,显示部分损伤的恢复。
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