Supramolecular Complexes of β-Cyclodextrin with Conjugated Fatty Acids: Synthesis and Stability

V. Nguyên, A. Dudina, V. Deineka, Thi Ngoc Lan Vu, L. Deineka, Maxim Yapryntev
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Abstract

The supramolecular complex formation in aqueous solution between fatty acids (with the content of αeleostearic acid more than 70%) and β-cyclodextrin, βCD, was supported by FT-IR and UV spectroscopies as well as by XRDanalysis. RP HPLC was utilized for investigation of the content of fatty acid in the inclusion complex and their stability. All results showed that the molecules of fatty acids were successfully included in the β-cyclodextrin cavity. The yield of the inclusion complex is up to 30.1% with a fatty acid content of 20.5%. Due to the formation of inclusion complex, the solubility, and stability of conjugated acids significant increase. Keywords—inclusion complexes, β-cyclodextrin, α-eleostearic acid, yield, composition
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β-环糊精与共轭脂肪酸的超分子配合物:合成与稳定性
红外光谱、紫外光谱和x射线分析证实了脂肪酸(α -骨酸含量大于70%)与β-环糊精(βCD)在水溶液中形成的超分子络合物。采用反相高效液相色谱法测定包合物中脂肪酸的含量及其稳定性。结果表明,脂肪酸分子被成功地包含在β-环糊精腔中。包合物产率达30.1%,脂肪酸含量为20.5%。由于包合物的形成,共轭酸的溶解度和稳定性显著提高。关键词:包合物,β-环糊精,α-骨脂酸,产率,组成
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