T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor
{"title":"Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes","authors":"T. Bancroft, B. Debuysscher, C. Weidle, A. Schwartz, A. Wall, M. Gray, Junli Feng, H. Steach, K. Fitzpatrick, M. Gewe, Patrick D. Skog, C. Doyle-Cooper, T. Ota, R. Strong, D. Nemazee, M. Pancera, L. Stamatatos, A. McGuire, Justin J. Taylor","doi":"10.1084/jem.20190164","DOIUrl":null,"url":null,"abstract":"An anti-idiotype recognizing the germline version of a broadly neutralizing antibody was utilized to identify human B cells expressing similar germline antibodies and was converted to an immunogen to stimulate transgenic murine B cells in vivo despite the presence of anergy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"97 1","pages":"2331 - 2347"},"PeriodicalIF":0.0000,"publicationDate":"2019-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190164","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
An anti-idiotype recognizing the germline version of a broadly neutralizing antibody was utilized to identify human B cells expressing similar germline antibodies and was converted to an immunogen to stimulate transgenic murine B cells in vivo despite the presence of anergy.
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