Acid Suppressant Activity of Feed Dietary Supplements for Dogs

Q3 Pharmacology, Toxicology and Pharmaceutics Journal of Pharmacy and Nutrition Sciences Pub Date : 2023-08-30 DOI:10.29169/1927-5951.2023.13.04
N. Bruni, E. Martello, Valeria Gabriele, Francesca Perondi
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Abstract

Gastritis is a common finding in pets and acid suppression plays an important role in its management. Acid suppression is the most important component in the treatment of gastritis and prevention of its complications. There are many drugs commonly used in veterinary medicine but the use of natural feed supplements is increasing. The aim of this in vitro study is the comparison of four supplements based on a combination of antacid salts and natural products at two pH conditions (pH 2 and 4.5) and at five time points. In addition, we wanted to confirm the formation of the gel during the test. All the products demonstrated acid suppression activity. In particular, product A showed the best performance. All the products except one (product B) formed gel after five minutes from the beginning of the experiment confirming their protective activity. Based on this preliminary results, the product A resulted to be the most promising antacid and potentially gastric protective product compared to others.
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犬饲粮添加物的抑酸活性研究
胃炎在宠物中很常见,抑酸在其治疗中起着重要作用。抑酸是治疗胃炎及预防其并发症的重要组成部分。兽药中有许多常用药物,但天然饲料补充剂的使用正在增加。这项体外研究的目的是在两种pH条件下(pH 2和4.5)和五个时间点比较四种基于抗酸盐和天然产物组合的补充剂。另外,我们想确认在测试过程中凝胶的形成情况。所有产物均表现出抑酸活性。特别是产品A表现出最好的性能。除一种产品(产品B)外,所有产品在实验开始5分钟后形成凝胶,证实其保护活性。基于这些初步结果,与其他产品相比,产品A是最有前途的抗酸和潜在的胃保护产品。
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来源期刊
Journal of Pharmacy and Nutrition Sciences
Journal of Pharmacy and Nutrition Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
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