Le Nhat Thuy Giang, D. T. T. Anh, Nguyen Ha Thanh, H. T. Phuong, Nguyen Tuan Anh, Nguyen Thi Quynh Giang, Vu Thi Thai Ha, N. Tuyen
{"title":"A Green and Efficient NH4OAc-catalyzed Synthesis of 2-Hydroxy-3-(arylmethyl)(4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl)-1,4-naphthoquinones","authors":"Le Nhat Thuy Giang, D. T. T. Anh, Nguyen Ha Thanh, H. T. Phuong, Nguyen Tuan Anh, Nguyen Thi Quynh Giang, Vu Thi Thai Ha, N. Tuyen","doi":"10.25073/2588-1140/vnunst.5353","DOIUrl":null,"url":null,"abstract":"The green and efficient approach for synthesis of 2-hydroxy-3-(arylmethyl)(4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl)-1,4-naphthoquinones starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and aromatic aldehydes was developed. These reactions were carried out in ethanol under microwave irradiation in the presence of ammonium acetate as catalyst. These multicomponent domino reactions presumably occur via NH4OAc-catalyzed Mannich reaction - Michael addition - hydration - tautomerism - elimination sequence of reactions.","PeriodicalId":23524,"journal":{"name":"VNU Journal of Science: Natural Sciences and Technology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"VNU Journal of Science: Natural Sciences and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25073/2588-1140/vnunst.5353","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
The green and efficient approach for synthesis of 2-hydroxy-3-(arylmethyl)(4-hydroxy-2-oxo-2,5-dihydrofuran-3-yl)-1,4-naphthoquinones starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and aromatic aldehydes was developed. These reactions were carried out in ethanol under microwave irradiation in the presence of ammonium acetate as catalyst. These multicomponent domino reactions presumably occur via NH4OAc-catalyzed Mannich reaction - Michael addition - hydration - tautomerism - elimination sequence of reactions.
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