Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance

Mytrang H Do, Xinxin Wang, Xian Zhang, Chun Chou, Briana G. Nixon, Kristelle J. Capistrano, Min Peng, A. Efeyan, D. Sabatini, Ming O. Li
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引用次数: 24

Abstract

Rag GTPase–dependent nutrient mTORC1 signaling plays a critical role in control of T reg cell suppression of autoimmunity and tumor immunity. These findings establish nutrients as a novel class of signaling molecule.
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营养mTORC1信号支持调节性T细胞控制免疫耐受
Rag gtpase依赖的营养物质mTORC1信号在T细胞抑制自身免疫和肿瘤免疫中起关键作用。这些发现确立了营养物质是一类新的信号分子。
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