Formulation and evaluation of transdermal patches containing dexketoprofen trometamol

International Journal of Pharmaceutical Chemistry Pub Date : 2020-07-24 DOI:10.18231/j.ijpca.2020.014

D. Trivedi, A. Goyal

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引用次数: 7

Abstract

Dexketoprofen Trometamol is a NSAID, used as an analgesic and anti-inflammatory drug. It works by blocking the action of cyclo-oxygenase in the body. Conventional route of delivery has many drawbacks such as hepatic first-pass metabolism, reduced bioavailability, and fluctuating drug concentrations in the blood. These problems can be overcome by development of transdermal drug delivery system. The objective of this study was to develop and evaluate the transdermal patches of the drug Dexketoprofen Trometamol. The patches were prepared by solvent casting method using polymers; Ethyl cellulose, HPMC and ERS 100 in different ratios. The prepared formulations were uniform in their physical characteristics. The formulation F6, combination of polymer (HPMC: EC in ratio 4:1) showed maximum release of 85.77% in 24 hours. The resultant data was fitted in to zero, first, Higuchi and Peppas model. The results specify that Dexketoprofen Trometamol transdermal patch can be designed for obtaining better therapeutic benefits. Keywords: Transdermal drug delivery system, TDDS, Skin patches, Kinetics, NSAIDs, Analgesic, Invitro and exvivo drug release.

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含dexketoprofen trometamol透皮贴剂的配方及评价

右酮洛芬是一种非甾体抗炎药，用作止痛和消炎药。它通过阻断体内环加氧酶的作用而起作用。传统的给药途径存在肝脏首过代谢、生物利用度降低和血液中药物浓度波动等缺点。这些问题可以通过开发经皮给药系统来克服。本研究的目的是开发和评价药物右酮洛芬曲美他莫的透皮贴剂。采用聚合物溶剂浇铸法制备贴片;乙基纤维素、HPMC和ERS100的不同配比。所制备的制剂物理性质均匀。聚合物组合F6 (HPMC: EC: 4:1)在24 h内的最大释放度为85.77%。所得数据首先被拟合到零，Higuchi和Peppas模型。结果表明，可以设计Dexketoprofen trometamol透皮贴剂，以获得更好的治疗效果。关键词:经皮给药系统，TDDS，皮肤贴片，动力学，非甾体抗炎药，镇痛，体外和体外药物释放

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International Journal of Pharmaceutical Chemistry

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