A new method was proposed using RP-UPLC for the determination of Gitingensine in bulk, which exhibits its power of stability output. Gitingensine is a natural product found in Kibatalia laurifolia belonging to Apocynaceae which is a steroid having the activities such as anti-inflammatory, anti-spasmodic and anti-cancer activity. Cevadine is used as an internal standard for chromatographic analysis. The elution was performed on BEH C18 (2.1 × 50 mm, 1.7 µm) column at 30 °C with a mobile phase distribution Acetonitrile: 0.1% orthophosphoric acid (60: 40) respectively. The flow rate was well- kept at 0.3 mL min-1. Retention times for Gitingensine and Cevadine were found to be 2.005 and 1. 395 min, respectively. The regression equation was found to be linear in the range of 12.5 – 75 µg/mL with a high correlation coefficient (0.999). Recovery of Gitingensine was obtained as 100.04%. Validation was done as claimed by ICH guidelines with respect to accuracy, sensitivity, robustness, and precision studies. From the insignificant variations in the analysis by changing the mobile phase, temperature, and flow rate, the robustness was studied. All the validation parameters were found to be within the specifications. Forced degradation studies revealed that when the influence of acid, alkali, peroxide, thermal, photolytic, and hydrolytic conditions were applied on the drug, it was stable. Hence, it can be concluded that the developed RP-UPLC method is economical, precise, and robust and can be adopted in regular Quality control analysis.
采用RP-UPLC定量测定木腥草素，显示出良好的稳定性输出能力。甲壳素是夹竹桃科的一种天然产物，是一种具有抗炎、抗痉挛、抗癌等活性的甾体化合物。切瓦定用作色谱分析的内标。色谱柱为BEH C18 (2.1 × 50 mm, 1.7µm)，流动相为乙腈:0.1%正磷酸(60:40)，温度为30℃。流速保持在0.3 mL min-1。丁香素和切瓦定的保留率分别为2.005和1。分别是395分钟。回归方程在12.5 ~ 75µg/mL范围内呈良好的线性关系，相关系数为0.999。甲壳素的回收率为100.04%。按照ICH指南关于准确性、敏感性、稳健性和精密度研究的要求进行验证。从流动相、温度和流量变化对分析结果的不显著影响出发，研究了鲁棒性。所有的验证参数都在规范范围内。强制降解研究表明，在酸、碱、过氧化物、热、光解和水解条件的影响下，药物是稳定的。由此可见，所建立的RP-UPLC方法经济、准确、稳健性好，可用于常规的质量控制分析。
{"title":"Stability indicating novel analytical method development by RP-UPLC for the estimation of Gitingensine in bulk","authors":"Sowmya Panduri, Theja Indireddy, Ramya Kuber Banoth","doi":"10.14805/jphchem.2022.art128","DOIUrl":"https://doi.org/10.14805/jphchem.2022.art128","url":null,"abstract":"A new method was proposed using RP-UPLC for the determination of Gitingensine in bulk, which exhibits its power of stability output. Gitingensine is a natural product found in Kibatalia laurifolia belonging to Apocynaceae which is a steroid having the activities such as anti-inflammatory, anti-spasmodic and anti-cancer activity. Cevadine is used as an internal standard for chromatographic analysis. The elution was performed on BEH C18 (2.1 × 50 mm, 1.7 µm) column at 30 °C with a mobile phase distribution Acetonitrile: 0.1% orthophosphoric acid (60: 40) respectively. The flow rate was well- kept at 0.3 mL min-1. Retention times for Gitingensine and Cevadine were found to be 2.005 and 1. 395 min, respectively. The regression equation was found to be linear in the range of 12.5 – 75 µg/mL with a high correlation coefficient (0.999). Recovery of Gitingensine was obtained as 100.04%. Validation was done as claimed by ICH guidelines with respect to accuracy, sensitivity, robustness, and precision studies. From the insignificant variations in the analysis by changing the mobile phase, temperature, and flow rate, the robustness was studied. All the validation parameters were found to be within the specifications. Forced degradation studies revealed that when the influence of acid, alkali, peroxide, thermal, photolytic, and hydrolytic conditions were applied on the drug, it was stable. Hence, it can be concluded that the developed RP-UPLC method is economical, precise, and robust and can be adopted in regular Quality control analysis.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75639119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Global competitions have made the pharmaceutical industry undergo numerous obstacles to meet up with the pace of drug discovery, growth and expansion. In order to effectively manufacture a quality product, statistical methods can be implemented for continuous improvement. Evolution in quality is accessed by determining the beneficial effects due to changes in process performance. The use of statistical tools and statistical methods have increased exponentially to meet specifications of quality during the development of pharmaceutical product. Statistical process control is a segment of industrial statistics utilized for the continuous improvement in the product quality. Statistical process control technique is a method to analyse any variation by the process of timely evaluation of the manufacturing procedure.
{"title":"Review on statistical methods applied in pharmaceutical quality control and quality assurance","authors":"Aishwarya Karan, Venkatesan Jayaprakash, Manik Ghosh","doi":"10.14805/jphchem.2022.art122","DOIUrl":"https://doi.org/10.14805/jphchem.2022.art122","url":null,"abstract":"Global competitions have made the pharmaceutical industry undergo numerous obstacles to meet up with the pace of drug discovery, growth and expansion. In order to effectively manufacture a quality product, statistical methods can be implemented for continuous improvement. Evolution in quality is accessed by determining the beneficial effects due to changes in process performance. The use of statistical tools and statistical methods have increased exponentially to meet specifications of quality during the development of pharmaceutical product. Statistical process control is a segment of industrial statistics utilized for the continuous improvement in the product quality. Statistical process control technique is a method to analyse any variation by the process of timely evaluation of the manufacturing procedure.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85515402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-15DOI: 10.18231/J.IJPCA.2021.006
H. Jamal, Shila Jain, Vandana
The Athlete Biological Passport (ABP) is an indirect approach which provides a complementary and more sophisticated strategy to traditional analytical testing in an effort to scientifically gather evidence of possible doping in sport. The ABP is one tool in a kit of intelligent anti-doping practices meant to deter and detect the use of prohibited substances in sport. In 2013, the WADA Athlete Biological Passport Guidelines introduced a second module, the Steroidal Module, which became operational since January 1, 2014. The Steroidal Module monitors an athlete’s steroidal variables over time that may be indicative of steroid abuse. This paper summarized the details of samples requested for confirmation on GC/C/IRMS in year 2015 & 2016 to understand the pattern of generation of Atypical Passport Finding Confirmation Procedure Request (ATPF-CPR). Interestingly, out of total 26 cases of ATPF-CPR received by NDTL, three samples with normal steroid profile showed exogenous origin of endogenous steroids on GC/C/IRMS analysis, which proves the effectiveness of Steroidal Module. In this context, monitoring of steroid passport through steroidal module represents the new paradigm in detection of exogenous origin of endogenous steroids. Keywords: ABP, Steroid Profile, SSPCPR, ATPFCPR, Endogenous, Exogenous.
{"title":"Implementation of steroidal passport: Experiences of Indian laboratory","authors":"H. Jamal, Shila Jain, Vandana","doi":"10.18231/J.IJPCA.2021.006","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.006","url":null,"abstract":"The Athlete Biological Passport (ABP) is an indirect approach which provides a complementary and more sophisticated strategy to traditional analytical testing in an effort to scientifically gather evidence of possible doping in sport. The ABP is one tool in a kit of intelligent anti-doping practices meant to deter and detect the use of prohibited substances in sport. In 2013, the WADA Athlete Biological Passport Guidelines introduced a second module, the Steroidal Module, which became operational since January 1, 2014. The Steroidal Module monitors an athlete’s steroidal variables over time that may be indicative of steroid abuse. This paper summarized the details of samples requested for confirmation on GC/C/IRMS in year 2015 & 2016 to understand the pattern of generation of Atypical Passport Finding Confirmation Procedure Request (ATPF-CPR). Interestingly, out of total 26 cases of ATPF-CPR received by NDTL, three samples with normal steroid profile showed exogenous origin of endogenous steroids on GC/C/IRMS analysis,\u0000which proves the effectiveness of Steroidal Module. In this context, monitoring of steroid passport through steroidal module represents the new paradigm in detection of exogenous origin of endogenous steroids.\u0000\u0000Keywords: ABP, Steroid Profile, SSPCPR, ATPFCPR, Endogenous, Exogenous.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"59 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91036053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-15DOI: 10.18231/J.IJPCA.2021.002
U. Shah, Aarti Patel, Rutu Patel, Mehul M. Patel, Ashish D. Patel, M. Kavad, Esha Desai
The pharmaceutical industry and most particularly the biopharmaceutical industry are demanding advancements in analytical techniques. The field of proteomics and peptide mapping needs sensitive analysis and sophisticated instrumentation, which needs hyphenated analytical techniques to be explored. In addition to effective detection and characterization, Due to efficient and selective separation, predominant focus has been drawn to capillary electrophoresis/mass spectrometry (CE/MS) compared to widely used techniques such as slab-gel electrophoresis (SGE), liquid chromatography (LC) and capillary electrophoresis (CE) Several significant advances in CE/MS instrumentation and software have made CE/MS a competitive tool in the last decade to solve a wide variety of analytical and biopharmaceutical problems. This analysis discusses the technological aspects of CE / MS interfaces, analytical separation modes, MS analyzer, recent CE / MS approaches and applications specific to biopharmaceutical. Applications using some of the more common electrophoretic separation modes, such as conventional electrophoresis of the capillary zone (CZE) and capillary isoelectric focusing (CIEF), have been highlighted. The peptide analysis also includes recent studies on capillary electro-chromatography (CEC) / MS and CE-MS applications. Keywords: Capillary electrophoresis, Mass spectrometry, Pharmaceutical applications, Peptide analysis, Proteomics, Intact protein.
{"title":"Overview on capillary electrophoresis with mass spectrometry: Application in peptide analysis and proteomics","authors":"U. Shah, Aarti Patel, Rutu Patel, Mehul M. Patel, Ashish D. Patel, M. Kavad, Esha Desai","doi":"10.18231/J.IJPCA.2021.002","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.002","url":null,"abstract":"The pharmaceutical industry and most particularly the biopharmaceutical industry are demanding advancements in analytical techniques. The field of proteomics and peptide mapping needs sensitive analysis and sophisticated instrumentation, which needs hyphenated analytical techniques to be explored. In addition to effective detection and characterization, Due to efficient and selective separation, predominant focus has been drawn to capillary electrophoresis/mass spectrometry (CE/MS) compared to widely used techniques such as slab-gel electrophoresis (SGE), liquid chromatography (LC) and capillary electrophoresis (CE) Several significant advances in CE/MS instrumentation and software have made\u0000CE/MS a competitive tool in the last decade to solve a wide variety of analytical and biopharmaceutical problems. This analysis discusses the technological aspects of CE / MS interfaces, analytical separation modes, MS analyzer, recent CE / MS approaches and applications specific to biopharmaceutical. Applications using some of the more common electrophoretic separation modes, such as conventional\u0000electrophoresis of the capillary zone (CZE) and capillary isoelectric focusing (CIEF), have been highlighted. The peptide analysis also includes recent studies on capillary electro-chromatography (CEC) / MS and CE-MS applications.\u0000\u0000Keywords: Capillary electrophoresis, Mass spectrometry, Pharmaceutical applications, Peptide analysis, Proteomics, Intact protein.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"25 1","pages":"6-15"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89885988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-15DOI: 10.18231/J.IJPCA.2021.001
T. Mahato
Antibiotic, antiviral, antifungal and antiparasitic medicines are used to treat the diseases caused by pathogenic microorganisms. These microbes effects humans, animals and plants and produces diseases. As per the recent report of World Health Organization (WHO), the cases of Antimicrobial resistance (AMR) is continuously rising, which causes ineffective treatment and prevention of infections caused by bacteria, viruses, fungi and parasites. AMR occurs when these microbes gets resistance and the medications gets ineffective against these microbes, which makes treatment of common infections difficult and consequently increases the risk of severe illness, spread of disease and death. Because the medicines becomes purposeless, infections continue to exist in the body and increases the likeliness of spread to others. WHO recommends reduced use of synthetic antibiotics and raised use of herbal antimicrobial drugs. These are the ways by which the AMR can be controlled or abolished. Herbal drugs can be used for this purpose because these are considered to be effective with no or less side effects. In the present article we discussed about peptic ulcer, causative agent of peptic ulcer and the medicinal plants which can be used to treat this disease. Twenty medicinal plants were listed which contains both antibacterial and antiulcer activity. Due to these properties of these medicinal plants, these can be used for the treatment of peptic ulcer because of dual benefits firstly, antibacterial which kills or retards the growth of Helicobacter pylori and secondly, antiulcer which heals the ulcer. Keywords: Antibacterial, Antimicrobial resistance, Antiulcer, Helicobacter pylori, Peptic ulcer.
{"title":"Herbal drugs: Boon for Peptic ulcer patients","authors":"T. Mahato","doi":"10.18231/J.IJPCA.2021.001","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.001","url":null,"abstract":"Antibiotic, antiviral, antifungal and antiparasitic medicines are used to treat the diseases caused by pathogenic microorganisms. These microbes effects humans, animals and plants and produces diseases. As per the recent report of World Health Organization (WHO), the cases of Antimicrobial resistance (AMR) is continuously rising, which causes ineffective treatment and prevention of infections caused by bacteria, viruses, fungi and parasites. AMR occurs when these microbes gets resistance and the medications gets ineffective against these microbes, which makes treatment of common infections difficult and consequently increases the risk of severe illness, spread of disease and death. Because the medicines\u0000becomes purposeless, infections continue to exist in the body and increases the likeliness of spread to others. WHO recommends reduced use of synthetic antibiotics and raised use of herbal antimicrobial drugs. These are the ways by which the AMR can be controlled or abolished. Herbal drugs can be used for this purpose because these are considered to be effective with no or less side effects. In the present article we discussed about peptic ulcer, causative agent of peptic ulcer and the medicinal plants which can be used to treat this disease. Twenty medicinal plants were listed which contains both antibacterial and antiulcer activity. Due to these properties of these medicinal plants, these can be used for the treatment of peptic\u0000ulcer because of dual benefits firstly, antibacterial which kills or retards the growth of Helicobacter pylori and secondly, antiulcer which heals the ulcer.\u0000\u0000Keywords: Antibacterial, Antimicrobial resistance, Antiulcer, Helicobacter pylori, Peptic ulcer.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83002515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-15DOI: 10.18231/J.IJPCA.2021.007
Guntupalli Suma Geetika, S. Natekar, A. Shetti
There is considerate amount of stress which lies in the application of antibiotics in critically ill patients. A study on pre-hospital antibiotic administration in such patients would provide crucial data and go a long way in determining and understanding trends in antibiotic prescribing, to identify where necessary steps to be taken to improve prescribing are most needed and to measure progress. Materials and Methods: After ethical committee approval, we have conducted an observational crosssectional study for four months. We collected the data from patient or the relatives regarding prehospital antibiotic therapy on admission. Results: A total of 137 patients got admitted in the Medical intensive care unit (MICU) during the study period. Out of them, 91.24% of patients got admitted directly in MICU and 8.75% were referred from different hospitals. Those who received antibiotics prior to the admission were 2.18% and 93.43% of patients had not received antibiotics; the other patients who were not sure of antibiotic consumption were 4.37%. Among those 2.18% of patients who received, it was observed the most commonly utilized first antibiotic in our study was amoxicillin clavulanate potassium 66.66%. In all the patients that received more than one antibiotic, Metronidazole was the second antibiotic that was administered via intravenous route. Conclusion: Amoxicillin clavulanate potassium was the most commonly and metronidazole was the second most antibiotic prescribed in prehospital admission. Proper guidelines should be initiated for the starting of the antibiotic therapies in India for general practitioners. Keywords: Antibiotics, Incidence, Prehospital, Critically ill.
{"title":"To study the incidence of pre-hospital antibiotic therapy among critically ill patients admitted in rural tertiary care hospital","authors":"Guntupalli Suma Geetika, S. Natekar, A. Shetti","doi":"10.18231/J.IJPCA.2021.007","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.007","url":null,"abstract":"There is considerate amount of stress which lies in the application of antibiotics in critically ill patients. A study on pre-hospital antibiotic administration in such patients would provide crucial data and go a long way in determining and understanding trends in antibiotic prescribing, to identify where necessary steps to be taken to improve prescribing are most needed and to measure progress.\u0000Materials and Methods: After ethical committee approval, we have conducted an observational crosssectional study for four months. We collected the data from patient or the relatives regarding prehospital antibiotic therapy on admission.\u0000Results: A total of 137 patients got admitted in the Medical intensive care unit (MICU) during the study period. Out of them, 91.24% of patients got admitted directly in MICU and 8.75% were referred from different hospitals. Those who received antibiotics prior to the admission were 2.18% and 93.43% of patients had not received antibiotics; the other patients who were not sure of antibiotic consumption were 4.37%. Among those 2.18% of patients who received, it was observed the most commonly utilized first antibiotic in our study was amoxicillin clavulanate potassium 66.66%. In all the patients that received more than one antibiotic, Metronidazole was the second antibiotic that was administered via intravenous route.\u0000Conclusion: Amoxicillin clavulanate potassium was the most commonly and metronidazole was the second most antibiotic prescribed in prehospital admission. Proper guidelines should be initiated for the starting of the antibiotic therapies in India for general practitioners.\u0000\u0000Keywords: Antibiotics, Incidence, Prehospital, Critically ill.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"46 1","pages":"32-35"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82089158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-15DOI: 10.18231/J.IJPCA.2021.005
A. Shetti, P. Ahiwale
A 23-year male patient came to Rural Tertiary Care Hospital with complaints of fever, difficulty in talking, disorientation and neck stiffness and was diagnosed with Dengue. When Dengue antibody testing was done, IgM was positive while IgG and NS1 being negative. We report an evaluation of an IgM seropositive case for dengue who showed neurological manifestation whose MRI Brain suggested Meningitis. CSF examination suggested Tuberculous Meningitis in the course of the infection. The patient responded to medications during hospitalisation, was discharged in a haemodynamically stable condition and was advised to continue with antitubercular treatment and tapering dose of oral steroids. Hence one should not avoid considering a Cerebrospinal fluid examination especially of patients belonging to Dengue endemic areas. Keywords: CSF examination, Dengue, Meningitis, Tuberculosis.
{"title":"Tuberculous Meningitis with dengue – A rare case","authors":"A. Shetti, P. Ahiwale","doi":"10.18231/J.IJPCA.2021.005","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2021.005","url":null,"abstract":"A 23-year male patient came to Rural Tertiary Care Hospital with complaints of fever, difficulty in talking, disorientation and neck stiffness and was diagnosed with Dengue. When Dengue antibody testing was done, IgM was positive while IgG and NS1 being negative. We report an evaluation of an IgM seropositive case for dengue who showed neurological manifestation whose MRI Brain suggested Meningitis. CSF examination suggested Tuberculous Meningitis in the course of the infection. The patient responded to medications during hospitalisation, was discharged in a haemodynamically stable condition and was advised to continue with antitubercular treatment and tapering dose of oral steroids. Hence one should not avoid considering a Cerebrospinal fluid examination especially of patients belonging to Dengue endemic areas.\u0000\u0000Keywords: CSF examination, Dengue, Meningitis, Tuberculosis.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"10 1","pages":"25-27"},"PeriodicalIF":0.0,"publicationDate":"2021-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87789171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-15DOI: 10.18231/J.IJPCA.2020.026
S. Deshpande, D. P. Mali
As the development of any drug and that too antiviral drug always requires time, in this Corona virus pandemic no specific drugs have been approved for coronavirus disease 2019 (COVID-19) till date. Therefore, assessment, analysis and use of currently available antiviral drugs become a challenge for medical field for a timely response to the current pandemic. Here, we have tried review anti CoV-2 potencies of available reverse transcriptase antiviral drugs. Several clinical trials are going on worldwide on variety of options but no specific solution in the form of vaccine or drug developed. Keywords: COVID 19, SARS, Remdesivir.
{"title":"Reverse transcriptase inhibitors: Potential drug delivery combating COVID-19","authors":"S. Deshpande, D. P. Mali","doi":"10.18231/J.IJPCA.2020.026","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2020.026","url":null,"abstract":"As the development of any drug and that too antiviral drug always requires time, in this Corona virus pandemic no specific drugs have been approved for coronavirus disease 2019 (COVID-19) till date. Therefore, assessment, analysis and use of currently available antiviral drugs become a challenge for medical field for a timely response to the current pandemic. Here, we have tried review anti CoV-2 potencies of available reverse transcriptase antiviral drugs. Several clinical trials are going on worldwide on variety of options but no specific solution in the form of vaccine or drug developed.\u0000\u0000Keywords: COVID 19, SARS, Remdesivir.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"32 1","pages":"161-165"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84595882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-15DOI: 10.18231/J.IJPCA.2020.028
Charushila J. Bhangale, S. Hiremath
The objective of the present work is to develop a simple, precise, accurate, validated stability indicating RPHPLC method for the determination of Phenazone and Lidocaine hydrochloride in bulk and tablet dosage form. The HPLC separation was achieved on Agilent TC C18 (2) 250 x 4.6 mm, 5 m column using mobile phase composition of phosphate buffer pH 2.5, acetonitrile, Methanol 70:20:10 (V/V/V). Flow rate was maintained at 1.5 ml/min at an ambient temperature. Quantification was achieved with ultraviolet detection at 230 nm. The retention time obtained for Lidocaine hydrochloride was at 7.2 min of and Phenazone was at 10.1 min. The result obtained with the detector response was found to be linear in the concentration range of 50-150 mg/ml for Phenazone and 10-70 mg/ml for Lidocaine Hydrochloride. The reliability and analytical performance of the proposed methods, including linearity, range, precision, accuracy, detection and quantitation limits, were statistically validated. When of Phenazone and Lidocaine hydrochloride was subjected to different stress conditions; the proposed methods could effectively separate the drug from its degradation products, and were thus considered as good stability-indicating procedures. It is concluded that this method can be applied for routine quality control of Phenazone and Lidocaine Hydrochloride in dosage forms as well as in bulk drug. Keywords: Phenazone, Lidocaine hydrochloride, Lidophen ear drop, Method development and validation, Stability indicating.
{"title":"Validated stability indicating RP-HPLC method for the determination of phenazone and lidocaine hydrochloride in bulk and dosage form","authors":"Charushila J. Bhangale, S. Hiremath","doi":"10.18231/J.IJPCA.2020.028","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2020.028","url":null,"abstract":"The objective of the present work is to develop a simple, precise, accurate, validated stability indicating RPHPLC method for the determination of Phenazone and Lidocaine hydrochloride in bulk and tablet dosage form. The HPLC separation was achieved on Agilent TC C18 (2) 250 x 4.6 mm, 5 m column using mobile phase composition of phosphate buffer pH 2.5, acetonitrile, Methanol 70:20:10 (V/V/V). Flow rate was maintained at 1.5 ml/min at an ambient temperature. Quantification was achieved with ultraviolet detection at 230 nm. The retention time obtained for Lidocaine hydrochloride was at 7.2 min of and Phenazone was at 10.1 min. The result obtained with the detector response was found to be linear in the concentration range of 50-150 mg/ml for Phenazone and 10-70 mg/ml for Lidocaine Hydrochloride. The reliability and analytical performance of the proposed methods, including linearity, range, precision, accuracy, detection and quantitation limits, were statistically validated. When of Phenazone and Lidocaine hydrochloride was subjected to different stress conditions; the proposed methods could effectively separate the drug from its degradation products, and were thus considered as good stability-indicating procedures. It is concluded that this method can be applied for routine quality control of Phenazone and Lidocaine Hydrochloride in dosage forms as well as in bulk drug.\u0000\u0000Keywords: Phenazone, Lidocaine hydrochloride, Lidophen ear drop, Method development and validation, Stability indicating.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"3 1","pages":"172-178"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88646518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-15DOI: 10.18231/J.IJPCA.2020.025
Paroma Arefin, Md Shehan Habib, D. Chakraborty, S. Bhattacharjee, Suman Das, Debabrata Karmakar, D. Bhowmik
Microcapsules offer a wide variety of convenience in drug delivery when compared with conventional dosage forms. It is a unique carrier system for many pharmaceuticals. Microencapsulation is a potential process which prolongs the efficacy of drug significantly and improves patient compliance. This approach can alleviate the limitations of dose dumping, multiple dose inconvenience, kidney disease. This dosage form has potential advantages for elderly people who have to take multiple drugs. But microcapsule preparation needs method and formulation optimization and proper characterization. In this review paper, we have discussed the advantages, limitation of the microcapsules and microspheres. We have highlighted the applications of microcapsules and microspheres in the pharmaceutical industries. We also discussed the characterization process of microcapsules. Microcapsules open the era of individualized, targeted drug delivery with minimal side effects and greater convenience. Keywords: Microencapsulation, Microspheres, Microcapsules, Characterization of microspheres, Application of microspheres.
{"title":"An overview of microcapsule dosage form","authors":"Paroma Arefin, Md Shehan Habib, D. Chakraborty, S. Bhattacharjee, Suman Das, Debabrata Karmakar, D. Bhowmik","doi":"10.18231/J.IJPCA.2020.025","DOIUrl":"https://doi.org/10.18231/J.IJPCA.2020.025","url":null,"abstract":"Microcapsules offer a wide variety of convenience in drug delivery when compared with conventional dosage forms. It is a unique carrier system for many pharmaceuticals. Microencapsulation is a potential process which prolongs the efficacy of drug significantly and improves patient compliance. This approach can alleviate the limitations of dose dumping, multiple dose inconvenience, kidney disease. This dosage form has potential advantages for elderly people who have to take multiple drugs. But microcapsule preparation needs method and formulation optimization and proper characterization. In this review paper, we have discussed the advantages, limitation of the microcapsules and microspheres. We have highlighted the applications of microcapsules and microspheres in the pharmaceutical industries. We also discussed the characterization process of microcapsules. Microcapsules open the era of individualized, targeted drug delivery with minimal side effects and greater convenience.\u0000\u0000Keywords: Microencapsulation, Microspheres, Microcapsules, Characterization of microspheres, Application of microspheres.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"281 1","pages":"155-160"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76793190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：