Xiuxiu Liu, Lin Yang, Ling-Xiao Shao, Yang He, Gang Wu, Y. Bao, Nan-nan Lu, Dong-Mei Gong, Yangyang Lu, Tian-Tian Cui, Ninghe Sun, Dan-yang Chen, W. Shi, K. Fukunaga, Hong-Shan Chen, Zhong Chen, Feng Han, Ying-Mei Lu
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引用次数: 32
Abstract
Liu et al. reveal a key mechanism that mediating the transition from cerebrovascular damage to epilepsy. They identify the endothelial cyclin-dependent kinase 5 (CDK5) regulates astrocytic glutamate reuptake and increased glutamate synaptic function through CXCL1/CXCR2-mediated astrogliosis.
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