Free-radical-scavenging activity and antioxidant effect of ascophyllan from marine brown algae Padina tetrastromatica

S. Mohsin, R. Mahadevan, G. Muraleedhara Kurup
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引用次数: 18

Abstract

Brown seaweeds are rich in sulfated polysaccharides that could potentially be exploited as functional ingredients for human health. Over the years, sulfated polysaccharides with potential pharmacological, nutraceutical and functional food properties have been isolated from brown seaweeds. This study was designed to characterise and evaluate the antioxidant activity of a sulfated polysaccharide ascophyllan isolated from marine brown algae Padina tetrastromatica. Four polysaccharide fractions were purified from crude ascophyllan. Antioxidant activities of the polysaccharide fractions were evaluated by various in vitro assay systems, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical-scavenging activity, lipid peroxidation and reducing power assay. The results showed that the ascophyllan fraction AF3 showed stronger free-radical-scavenging abilities and had good antioxidant effect. Available data obtained by in vitro models suggest that there is a correlation between the sulfate content and antioxidant activity.

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海洋褐藻叶青素的自由基清除活性及抗氧化作用
褐海藻富含硫酸多糖,可作为人体健康的功能性成分加以开发利用。多年来,从褐海藻中分离出具有潜在药理、营养和功能性食品特性的硫酸酸化多糖。本研究旨在表征和评价从海洋褐藻中分离的硫酸酸化葡萄树酚多糖的抗氧化活性。从粗葡萄树酚中纯化了4个多糖组分。通过2,2-二苯基-1-苦味酰肼(DPPH)、超氧阴离子、羟基自由基清除活性、脂质过氧化和还原能力等多种体外测定系统评价多糖组分的抗氧化活性。结果表明,葡萄叶青素部分AF3具有较强的自由基清除能力和良好的抗氧化作用。通过体外模型获得的现有数据表明,硫酸盐含量与抗氧化活性之间存在相关性。
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