Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas B. Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, C. Janus, Paramita Chakrabarty, Andrew R. Judge, T. Brusko, A. D. de Kloet, E. Krause, T. Golde
{"title":"An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes","authors":"Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas B. Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, C. Janus, Paramita Chakrabarty, Andrew R. Judge, T. Brusko, A. D. de Kloet, E. Krause, T. Golde","doi":"10.1084/jem.20190430","DOIUrl":null,"url":null,"abstract":"A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"43 1","pages":"2479 - 2491"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190430","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis.
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