Paola Tieppo, M. Papadopoulou, Deborah Gatti, N. McGovern, J. Chan, F. Gosselin, Glenn Goetgeluk, K. Weening, Ling Ma, N. Dauby, Alexandra Cogan, C. Donner, F. Ginhoux, B. Vandekerckhove, D. Vermijlen
{"title":"The human fetal thymus generates invariant effector γδ T cells","authors":"Paola Tieppo, M. Papadopoulou, Deborah Gatti, N. McGovern, J. Chan, F. Gosselin, Glenn Goetgeluk, K. Weening, Ling Ma, N. Dauby, Alexandra Cogan, C. Donner, F. Ginhoux, B. Vandekerckhove, D. Vermijlen","doi":"10.1084/jem.20190580","DOIUrl":null,"url":null,"abstract":"Tieppo et al. show that the human fetal thymus generates invariant γδ T cells with programmed effector functions. This is due to an intrinsic property of fetal HSPCs caused by high expression of the RNA-binding protein Lin28b.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"308 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"54","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20190580","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 54
Abstract
Tieppo et al. show that the human fetal thymus generates invariant γδ T cells with programmed effector functions. This is due to an intrinsic property of fetal HSPCs caused by high expression of the RNA-binding protein Lin28b.
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