Antidiabetic and antidyslipidemic nature of trigonelline, a major alkaloid of fenugreek seeds studied in high-fat-fed and low-dose streptozotocin-induced experimental diabetic rats

Sorimuthu Pillai Subramanian, Gopalan Sriram Prasath
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引用次数: 36

Abstract

Fenugreek (Trigonella foenum graecum) is one of the most widely used medicinal plants in folk medicine. It is known to have diuretic, cardio tonic, hypotensive, hypoglycemic and hypolipidemic effect. Trigonelline, a major alkaloid component of fenugreek, is reported to be responsible for most of its pharmacological activities. The present study was designed to investigate the effect of trigonelline on blood glucose, glycosylated hemoglobin and plasma insulin levels in high-fat-fed (HFD)/streptozotocin (STZ)-induced type 2 diabetic rats. Diabetes was induced by high-fat diet and low-dose STZ (35 mg/kg.b.wt). Diabetic rats were treated with trigonelline (150 mg/kg b.wt) for 30 days. The toxicological as well as biochemical parameters such as blood glucose, HbA1C, insulin, insulin resistance (HOMA-IR) and lipid profile were measured. The activities of serum AST, ALT and ALP were also assayed. Trigonelline supplementation attenuated the elevated levels of glucose, glycosylated hemoglobin, AST, ALT and ALP. The insulin level was improved with an improvement in hepatic and muscle glycogen content of insulin resistant diabetic rats. Trigonelline effectively normalized the status of lipid profile. These results showed that trigonelline have potential anti-hyperglycemic and antidyslipidemic effects in HFD/STZ-induced type 2 diabetic rats.

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葫芦巴种子中的主要生物碱葫芦巴碱在高脂肪喂养和低剂量链脲佐菌素诱导的实验性糖尿病大鼠中抗糖尿病和降血脂的作用
葫芦巴(Trigonella foenum graecum)是民间医学中应用最广泛的药用植物之一。具有利尿、强心、降压、降血糖、降血脂作用。葫芦巴碱是葫芦巴的主要生物碱成分,据报道,葫芦巴的大部分药理活性都是由葫芦巴碱产生的。本研究旨在探讨葫芦巴碱对高脂喂养(HFD)/链脲佐菌素(STZ)诱导的2型糖尿病大鼠血糖、糖化血红蛋白和血浆胰岛素水平的影响。高脂饮食加低剂量STZ (35 mg/kg.b.wt)诱导糖尿病。用葫芦巴碱(150 mg/kg b.wt)治疗糖尿病大鼠30天。测定毒理学及生化指标,如血糖、糖化血红蛋白、胰岛素、胰岛素抵抗(HOMA-IR)、血脂等。测定血清AST、ALT、ALP的活性。补充葫芦巴碱可降低葡萄糖、糖化血红蛋白、谷丙转氨酶和碱性磷酸酶的升高水平。胰岛素抵抗型糖尿病大鼠肝糖原和肌糖原含量提高,胰岛素水平也随之提高。葫芦巴碱有效地使血脂状况正常化。结果表明,葫芦巴碱对HFD/ stz诱导的2型糖尿病大鼠具有潜在的降血糖和降血脂作用。
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