Synthesis And Biological Evaluation of Some New Schiff base 1,2,4-Triazole Derivatives

Abstract

A series of substituted 1,2,4-Triazole derivatives were synthesized, and their anticonvulsant activity and antimicrobial activity were evaluated which include the MES model and by Cup-plate method. However, further studies need to be carried out to ascertain the precise mechanism of action of anticonvulsant activity of these molecules. The compounds 4-[1-(2-Bromo-phenyl)-ethylideneamino]-5-pyridin-3-yl-2,4-dihydro[1, 2, 4] triazole-3-thione (SB-1) and 4-[1-(4-Fluoro-phenyl)-ethylideneamino]-5-pyridin-3-yl-2,4-dihydro[1, 2, 4] triazole-3-thione (SB-2) showed significant anticonvulsant activity and antibacterial activity against Escherichia coli.