In vivo antimicrobial efficiency of garlic extract against pulmonary infections; Histopathological and Biochemical study

Abstract

As microbes are massively risky and have gotten to be safe to about all advertised anti-microbials. Withinthe period of anti-microbial resistance, antimicrobial of natural origin give an successful and cheap alternative for combating resistant strains of Gram negative microorganisms which induce pneumonia e.g. (P. aeruginosa) Pseudomonas aeruginosa and (K. pneumoniae) Klebsiella pneumoniae. Cefotaxime is an antimicrobial used in control and treatment of anaerobic bacteria which may be administered with Gentamicin within the treatment of blended contaminations caused by anaerobic and oxygen consuming living beings. Combination treatment has corresponding components of activity. Gentamicin is bactericidal aminoglycoside antibiotic used mainly against Gram negative bacteria. Allium sativum in garlic extract has been known to have inhibitory action & and valuable as helpful specialist against numerous pathological diseases. Expanding Multidrug resistance of pathogens strengths to discover elective strategies for treatment of irresistible infections. Methods: Ethical approval: Protocols were approved by the IRB of the Scientific Research Unit (SRU) at Inaya Medical College (IMC) RIYADH (KSA) Results: In-vitro and in-vivo antibacterial presented effect for combination of antibiotics and FGE for fourteen days. Indicated a significant (p homogenate. Our data showed that FGH combined antibiotics could protect the liver and kidney against the histopathological and histochemical changes by blocking oxidative damages in addition to restorement of the antioxidant enzymatic profile. Conclusion: FGE displayed the best effect on administration one hour before gentamicin and cefotaxime due to its anti-inflammatory and antioxidant effects. Moreover, the potential use of FGE as a prophylactic agent against multi drug resistant bacteria. Keywords: Pneumonia related infections, Gentamicin, Cefotaxime, Garlic, Histochemical and histopathological.