Obtaining Hydrogels based on PVP/PVAL/Chitosan Containing Pseudoboehmite Nanoparticles for Application in Drugs

Hydrogels Pub Date : 2017-12-20 DOI:10.5772/INTECHOPEN.72007

L. Miranda, Kátia Lucia Gonçalves Cunha, I. Barbosa, T. J. Masson, Antônio Hortencio Munhoz Junior

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引用次数: 3

Abstract

Peoplewithskinlesionscausedbyburns,ulcerationsandothercomplications,independentofdegreeandextensionoftheproblem,hasinducedthesearchformethodsandmaterialstooptimizetheprocessoftissuerepairinmatteroftimeandquality.Thus,materialsmadebysyntheticpolymershavebeenusedandimprovedduetooverwhelmingdemand.Theefficacyofdressingsandbandagedependsonavarietyoffactorssuchasbiocompatibility,compositionuniformity,lowcost,longvalidity,flexibility,andsoon.Inthischapter,hydro-philicmembranesbasedonpolyvinylpyrrolidone-PVP/poly(vinylalcohol)-PVAland chitosan containing nanoparticles of pseudoboehmite for use in pharmaceuticals were developed and studied. The hydrogels were obtained by ionizing radiation in electron-beam accelerator at a dose of 25 kGy and characterized by mechanical, thermal and physi- cochemicaltests.Pseudoboehmitenanoparticles wereobtainedfrom aluminumnitrate bya sol – gel process. The characterization of the hydrogels was done by various tests such as tensile, swelling, sol-gel fraction and dynamic mechanical analysis. The results show that the presence of PVAl hydrophilic membrane causes lower degree of swelling,greaterattractionandgreaterresistancetoelongationatbreakintension,althoughsignificantlylowerfractionofgelmembranescontainsonlyagarandPVP.Itwasverifiedthatthepresenceofchitosannanoparticlesandpseudoboehmitepromotesadecreaseintheformationofcross-linksduringirradiationofhydrophilicmembranes. with higher mechanical properties, the dose irradiation must be increased to increase the density of cross-links.

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基于PVP/PVAL/壳聚糖的伪薄水铝石纳米颗粒水凝胶的制备及其药物应用

Peoplewithskinlesionscausedbyburns, ulcerationsandothercomplications、independentofdegreeandextensionoftheproblem hasinducedthesearchformethodsandmaterialstooptimizetheprocessoftissuerepairinmatteroftimeandquality.Thus、materialsmadebysyntheticpolymershavebeenusedandimprovedduetooverwhelmingdemand.Theefficacyofdressingsandbandagedependsonavarietyoffactorssuchasbiocompatibility compositionuniformity,低成本,longvalidity,灵活性,andsoon.Inthischapter hydro-philicmembranesbasedonpolyvinylpyrrolido开发和研究了含伪薄水铝石纳米颗粒的聚乙烯吡咯烷酮/聚乙烯醇-聚乙烯醇-壳聚糖和壳聚糖。在电子束加速器中以25kgy的剂量电离辐射制备水凝胶，并通过力学、热学和物理化学测试对其进行了表征。以硝酸铝为原料，采用溶胶-凝胶法制备了伪纳米颗粒。通过拉伸、膨胀、溶胶-凝胶分数和动态力学分析等测试对水凝胶进行表征。结果表明，尽管壳聚糖和PVAl的含量显著降低，但PVAl亲水膜的溶胀程度较低，在断裂强度下具有更大的吸引力和更大的抗拉伸性。验证了壳聚糖纳米颗粒和假分子量的存在促进了亲水膜在辐照过程中交联形成的减少。对于力学性能较高的材料，必须加大辐照剂量以增加交联的密度。

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