Antihyperlipidemic effect of coumarin in experimental type 2 diabetic rats

Biomedicine & Preventive Nutrition Pub Date : 2014-04-01 DOI:10.1016/j.bionut.2014.02.003

Leelavinothan Pari, Narayanasamy Rajarajeswari, Settu Saravanan, Ayyasamy Rathinam

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引用次数: 16

Abstract

The present study was aimed to examine the hypolipidemic effect of coumarin on streptozotocin–nicotinamide induced type 2 diabetic rats. Diabetes mellitus was induced by single intraperitoneal injection of 45 mg/kg streptozotocin, 15 min after the intraperitoneal administration of 110 mg/kg nicotinamide. Streptozotocin–nicotinamide induced diabetic rats showed a significant increase in the levels of plasma and tissue (liver and kidney) lipids (total cholesterol, triglycerides, free fatty acids, phospholipids), LDL, VLDL and a significant decrease in the levels of HDL were observed. A significant increase in the activity of HMG-CoA reductase in tissues and significant decrease in the activities of LPL and LCAT in plasma were observed in type 2 diabetic rats. After oral administration of coumarin to diabetic rats, were found to alleviate the lipid profiles and lipid metabolizing enzymes. Conclusively, oral treatment of coumarin exhibited in a marked antihyperlipidemic effect against diabetes mellitus.

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香豆素对实验性2型糖尿病大鼠的降血脂作用

本研究旨在探讨香豆素对链脲佐菌素-烟酰胺诱导的2型糖尿病大鼠的降血脂作用。采用单次腹腔注射链脲佐菌素45 mg/kg，在烟酰胺110 mg/kg腹腔注射后15 min诱导糖尿病。链脲佐菌素-烟酰胺诱导的糖尿病大鼠血浆和组织(肝脏和肾脏)脂质(总胆固醇、甘油三酯、游离脂肪酸、磷脂)、LDL、VLDL水平显著升高，HDL水平显著降低。2型糖尿病大鼠组织中HMG-CoA还原酶活性显著升高，血浆中LPL和LCAT活性显著降低。糖尿病大鼠口服香豆素后，发现其脂质谱和脂质代谢酶均有所改善。总之，口服香豆素对糖尿病有明显的降血脂作用。

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Biomedicine & Preventive Nutrition

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