{"title":"Synthesis and Metabolic Studies of Cl4-Labeled Hemicholinium Number Three*","authors":"Floyd R. Domer , F.W. Schueler","doi":"10.1002/jps.3030490817","DOIUrl":null,"url":null,"abstract":"<div><p>Synthesis of C<sup>I4</sup>-labeled hemicholinium No. 3 (HC-3) with a specific activity of 2.788 mc./m<em>M</em> is described. Twenty-four hour studies of rats in metabolism cages indicated 57.5 per cent of an injected dose is excreted in the urine, 15.6 per cent is excreted in the feces, and none is excreted in the expired carbon dioxide. Tissue distribution studies did not show any site of localization in rats.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 8","pages":"Pages 553-556"},"PeriodicalIF":0.0000,"publicationDate":"1960-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030490817","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315362594","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Synthesis of CI4-labeled hemicholinium No. 3 (HC-3) with a specific activity of 2.788 mc./mM is described. Twenty-four hour studies of rats in metabolism cages indicated 57.5 per cent of an injected dose is excreted in the urine, 15.6 per cent is excreted in the feces, and none is excreted in the expired carbon dioxide. Tissue distribution studies did not show any site of localization in rats.
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