Preparation and In vitro Characterization of Valerianic Acid Loaded Polymeric Nanoparticles

Abstract

This article describe the preparation of valerianic acid loaded HPMC nanoparticles (NPs) using the nano-precipitation method. Objective of this study include enhancement of the dissolution rate of the poorly water soluble drug(Valerenic acid obtained from Valerianawallichii), and further more to look into the in vitro properties, zeta potential and surface characteristics of nanoparticles (percent yield of nanoparticles, percent encapsulation efficiency and in vitro release characteristics).In phosphate buffer medium at pH 6.8, the cumulative drug release from the original drug and nanoparticles were up to about 12% and 35%, respectively. Valerianic acid release can be enhanced by the use of nanoparticles loaded with hydroxy propyl methyl cellulose (HPMC), that also enhances bioavailability and patient compliance.