Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, P. Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, B. Ye, Yong Tian, Z. Fan
{"title":"Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription","authors":"Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, P. Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, B. Ye, Yong Tian, Z. Fan","doi":"10.1084/jem.20182363","DOIUrl":null,"url":null,"abstract":"Liu et al. show that Yeats4 recruits the Dot1l–RNA Pol II complex onto the Lmo4 promoter by recognizing H3K27ac modification to initiate Lmo4 transcription in α4β7+ CLPs, leading to ILC lineage commitment.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"64 1","pages":"2653 - 2668"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20182363","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
Liu et al. show that Yeats4 recruits the Dot1l–RNA Pol II complex onto the Lmo4 promoter by recognizing H3K27ac modification to initiate Lmo4 transcription in α4β7+ CLPs, leading to ILC lineage commitment.