Digital Realization of Ca2+ Oscillation With Impact of Amyloid-β

Abstract

Any dysregulation for intracellular Ca2+ dynamic with abnormally accumulation of Amyloid beta (Aβ) plaques can cause neuroinflammation which leads to the development of Alzheimer’s Disease (AD). In this paper, a multiplierless digital design with COordinate Rotation DIgital Computer (CORDIC) algorithm according to a biologically computational model including IP3 receptors (IPR), plasma membrane pump, a sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) pump, ryanodine receptors channels, and general membrane leak is represented. Hardware implementation and the numerical analysis illustrates that, the CORDIC-based intracellular Ca2+ dynamics can emulate the same biochemical behavior of the Ca2+ in cells with negligible variance.