Spectrophotometric Method for the Simultaneous Determination of Pseudoephedrine and Triprolidine in Bulk and Tablet Forms

Abstract

A spectrophotometric method was developed for the simultaneous determination of pseudoephedrine HCl (PSE) and triprolidine HCl (TRI) in bulk and dosage forms. The method involved the determination of pseudoephedrine in the presence of triprolidine using two wavelengths (257 nm & 290 nm). Beers law was obeyed in the concentration (152-760 ?g/ml) and (6.4-32 ?g/ml) with good linearity (0.9996 and 0.9996) for pseudoephedrine and triprolidine respectively. The accuracy and the precision of the developed method were very good (RSD ? 2%). The validity of the proposed method was confirmed through the statistical comparison of the obtained data with those of the official USP method.