{"title":"Effects of Tranquilizers on Bacterial Toxemias II. Meprobamate*","authors":"Leo Greenberg, James W. Ingalls","doi":"10.1002/jps.3030491008","DOIUrl":null,"url":null,"abstract":"<div><p>Pretreatment of rats and mice with meprobamate prior to inoculation with lethal doses of bacterial exotoxins and endotoxins resulted in a highly significant prolongation of life. However, the drug showed no effect on survival time in overwhelming infections induced by <em>Diplococcus pneumoniae</em> or <em>Salmonella typhimurium</em>. In <em>Salmonella enteritidis</em> infection, chlorpromazine increased the susceptibility of mice far more markedly than did meprobamate.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 10","pages":"Pages 657-659"},"PeriodicalIF":0.0000,"publicationDate":"1960-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491008","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Pharmaceutical Association (Scientific ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0095955315363393","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
Pretreatment of rats and mice with meprobamate prior to inoculation with lethal doses of bacterial exotoxins and endotoxins resulted in a highly significant prolongation of life. However, the drug showed no effect on survival time in overwhelming infections induced by Diplococcus pneumoniae or Salmonella typhimurium. In Salmonella enteritidis infection, chlorpromazine increased the susceptibility of mice far more markedly than did meprobamate.
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