{"title":"Chemical Constituents of Caesalpinia bonduc","authors":"Le Thi Huyen, Nguyen Thi Thu Hau","doi":"10.25073/2588-1140/vnunst.5500","DOIUrl":null,"url":null,"abstract":"This phytochemical investigation of Caesalpinia bonduc reported eight known compounds, namely threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-methoxy-propanol (1), evofolin-B (2), trans-Linalool-3,6-oxide-β-D-glucopyranoside (3), 1-(2-methylbutyryl)phloroglucinol-glucopyranoside (4), 1-(3 methylbutyryl)phloroglucinol-glucopyranoside (5), (+)-isolariciresinol (6), protocatechuic acid (7), methyl gallate (8). The structures of these compounds were identified by 1D- and 2D- nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) and by comparison with those reported in the literature. Compound 2 exhibited significant cytotoxic effects against the HepG2 cell line with an IC50 value of 48.37±3.18 µM.","PeriodicalId":23524,"journal":{"name":"VNU Journal of Science: Natural Sciences and Technology","volume":"15 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"VNU Journal of Science: Natural Sciences and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25073/2588-1140/vnunst.5500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This phytochemical investigation of Caesalpinia bonduc reported eight known compounds, namely threo-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-methoxy-propanol (1), evofolin-B (2), trans-Linalool-3,6-oxide-β-D-glucopyranoside (3), 1-(2-methylbutyryl)phloroglucinol-glucopyranoside (4), 1-(3 methylbutyryl)phloroglucinol-glucopyranoside (5), (+)-isolariciresinol (6), protocatechuic acid (7), methyl gallate (8). The structures of these compounds were identified by 1D- and 2D- nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) and by comparison with those reported in the literature. Compound 2 exhibited significant cytotoxic effects against the HepG2 cell line with an IC50 value of 48.37±3.18 µM.
本植物化学研究报告了八种已知化合物，分别为:三-2,3-二(4-羟基-3-甲氧基苯基)-3-甲氧基丙醇(1)、进化酚-b(2)、反式亚胺醇-3,6-氧化物-β- d -葡萄糖吡喃苷(3)、1-(2-甲基丁基)间苯三酚-葡萄糖吡喃苷(4)、1-(3 -甲基丁基)间苯三酚-葡萄糖吡喃苷(5)、(+)-异构体树脂醇(6)、原儿茶酸(7)、没有食子酸甲酯(8)。这些化合物的结构通过1D和2D核磁共振(NMR)光谱和质谱(MS)鉴定，并与文献报道的结构进行了比较。化合物2对HepG2细胞株具有明显的细胞毒作用，IC50值为48.37±3.18µM。
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