Time for a U-Turn on Understanding the Major Cause of Universal HumanHypovitaminosis D

Abstract

Vitamin D deficiency has turned into a rather concerning health issue around the globe, touching at least 40- 50% of general population. The old and stereotyped view with regard to the problem is that, the current hypovitaminosis D results from inadequate vitamin D in human diet and lack of enough sunlight exposure. And even more amusing is that the vast majority of recent epidemic human health problems are being somehow regarded as the direct outcome of this particular micronutrient deficiency. Our major aim in this brief overview, which will be followed by an opinion, is to cast a faint beam of light onto a narrow road towards a more sensible understanding of this utterly bizarre and poorly explained human health dilemma. We would like to raise the impression that the current vitamin D deficiency state is not merely a simple dietary inadequacy, but an immediate outcome of metabolic syndrome and its closely related medical entity, the nonalcoholic fatty liver disease (NAFLD). We would like to put forward the idea of vitamin D malabsorption and impaired 25-hydroxylation of vitamin D precursors in subjects affected by NAFLD, and to open a wide field of research in front of dedicated and loyal scientists.