Diamagnetic Zn(II) and Hg(II) Complexes with Fluconazole: Synthesis, Spectral Characterization and Biological Investigation

P. Keerthika, S. Balasubramaniyan, R. Govindharaju
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Abstract

In order to create new mononuclear diamagnetic complexes (M = Zn (II) and Hg (II)), fluconazole and thiocyanate ion ligands were utilized. Physicochemical and spectroscopic approaches were used to describe the synthesized metal complexes. The spectral data show that the fluconazole served as a bidentate ligand and linked to metal ions via the nitrogen of the imine group, the thiocyanate ion connected to metal ions through nitrogen. The antibacterial capacities of the strains of Candida albicans (MTCC 183) for fungi and Escherichia coli (MTCC 732) for bacteria were assessed using the disc diffusion method. The results showed that Zn (II) and Hg (II) complexes have much stronger antibacterial activity than pure ligands because of metal chelation. The complexes interactions with the stable free radical DPPH are measured. The free radical scavenging activities of the complexes and the ligand have been determined by measuring their interaction with the stable free radical DPPH. The complexes have larger antioxidant activity as compared to the ligands.
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抗磁性锌(II)和汞(II)与氟康唑配合物:合成、光谱表征和生物学研究
为了制备新的单核抗磁性配合物(M = Zn (II)和Hg (II)),利用了氟康唑和硫氰酸盐离子配体。采用物理化学和光谱学方法对合成的金属配合物进行了表征。光谱数据表明,氟康唑作为双齿配体通过亚胺基的氮与金属离子连接,硫氰酸盐离子通过氮与金属离子连接。采用圆盘扩散法测定白色念珠菌(MTCC 183)和大肠杆菌(MTCC 732)对真菌和细菌的抑菌能力。结果表明,由于金属螯合作用,Zn (II)和Hg (II)配合物比纯配体具有更强的抗菌活性。测定了配合物与稳定自由基DPPH的相互作用。通过测定配合物和配体与稳定自由基DPPH的相互作用,确定了配合物和配体的自由基清除活性。与配体相比,配合物具有更强的抗氧化活性。
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