Comparative effect of ginger (an anti-inflammatory medicinal herb) and aspirin (a non-steroidal anti-inflammatory drug) on cytoprotection and body weight changes in male albino Wistar rats

Abstract

Nonsteroidal anti-inflammatory medicines (NSAIDs) are used to treat acute and chronic musculoskeletal problems (osteoarthritis, rheumatoid arthritis, and gout injuries), headaches, dental aches, surgical pains, and dysmenorrhea. Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) can cause ulcers. Ginger, a common spice, is anti-inflammatory. Ginger's anti-inflammatory qualities make it suitable for the herbal treatment of inflammatory diseases in numerous cultures. This study examined the effects of ginger, an anti-inflammatory plant, and aspirin, a NSAID, on animal stomachs and body weight. Both are used to treat inflammatory conditions in various nations. Given that aspirin has been linked to stomach ulcers, the study sought to determine if ginger had a larger stomach cytoprotective impact. The study hopes to determine if ginger, a medicinal herb, might reduce inflammation and weight. This study used 45 male Wistar rats. Three 15-rat groups—Control, Ginger, and Aspirin—were created. Five (5) rats in each group were utilized to assess mucus, ulcer scores, and pepsin secretion from the 15 rats in each group. Three animal groups received food and water daily. For four weeks, ginger group mice received 150 mg/kg aqueous ginger extract, while aspirin group animals received 150 mg/kg aspirin. At the end of the trial, ginger group animals had considerably lower mucus secretion than the control and aspirin groups. At 0.05 significance difference, the ginger group's pepsin secretion was significantly higher than the control and aspirin groups, although the ulcer score was significantly higher in the aspirin group. Ginger and aspirin groups had lower body weight changes than the control group at 0.05 significant differences. Ginger may treat inflammatory diseases, according to ulcer scores, and decrease weight gain.