The protective effect of Matricaria pubescens extracts against alloxan-induced hyperglycemia in rats

Bollettino della Societa italiana di biologia sperimentale Pub Date : 2022-08-04 DOI:10.4081/jbr.2022.10441

Kherraz Khaled, Ghemam Amara Djilani, Laoudj Hacen, M. Mohmed, Chefrour Azedinne

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Abstract

This study aims to investigate the plausible inhibitory capacity of Matricaria pubescens methanolic extract (EMMP) on key diabetes-related enzymes in diabetic rats. A significant increase in the serum and pancreatic α-amylase activity in untreated diabetic rats (Diab) by 61% and 75% respectively produced a remarkable rise in blood glucose levels of 184% compared with the controls. However, the treatment of diabetic rats with the extract (Diab + EMMP) caused a significant decrease in pancreatic α-amylase activity in the pancreas (15%) and in serum (28%) compared to untreated diabetic rats. Therefore, a considerable reduction in blood sugar level has been observed reaching 28%. A significant decrease was observed in the glycated hemoglobin (HbA1c) level (28%) in rats treated with EMMP compared to untreated diabetics. Furthermore a significant increase in the pancreatic serum lipase activity (59%) compared to the control group, led to a distinguished inhibition (21%) in diabetic rats treated with EMMP. A potent protective action of β-cells was observed in diabetic rats treated with EMMP. However, we observed recovery in body weight in the diabetic rats treated with EMMP.

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毛茛提取物对四氧嘧啶诱导的大鼠高血糖的保护作用

本研究旨在探讨毛蕊草甲醇提取物(EMMP)对糖尿病大鼠糖尿病相关关键酶的抑制作用。与对照组相比，未经治疗的糖尿病大鼠(Diab)血清和胰腺α-淀粉酶活性分别显著增加61%和75%，血糖水平显著上升184%。然而，与未治疗的糖尿病大鼠相比，用提取物(Diab + EMMP)治疗糖尿病大鼠，胰腺α-淀粉酶活性(15%)和血清α-淀粉酶活性(28%)显著降低。因此，血糖水平显著降低，达到28%。与未治疗的糖尿病患者相比，EMMP治疗的大鼠糖化血红蛋白(HbA1c)水平显著降低(28%)。此外，与对照组相比，胰腺血清脂肪酶活性显著增加(59%)，导致EMMP治疗的糖尿病大鼠明显抑制(21%)。EMMP对糖尿病大鼠有明显的保护作用。然而，我们观察到EMMP治疗的糖尿病大鼠体重恢复。

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Bollettino della Societa italiana di biologia sperimentale

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