Review on Reverse Pharmacology of Jawarhar Mahakashaya Drugs for Anti-pyretic Activity in Momoherbal and Polyherbal Form

Abstract

Ayurvedic Jawarahara Mahakashaya (JhMh) includes Sariva, Sharkara, Patha, Manjishtha, Draksha, Pilu, Parushaka, Abhaya, Amalaka and Bibhitaka drugs as a set of ten herbal drugs, means this set of drug is effective in countering Jawar (fever) in single drug form or combined formulation. Globally the most accepted drugs which are used to cure pyrexia are NSAIDS. It is reported that most of these chemical antipyretic formulations has been associated with gastrointestinal, renal, hepatic, CNS and dermatological side effects. Extensive literature searches both electronic online databases on concerning issues. Drugs of Jawarhar Mahakashaya in monoherbal and polyherbal form have shown significant antipyretic activity in pre-clinical set up as mentioned in Ayurvedic literatures. The main aim of this paper is to review reverse pharmacology of JhMh drugs is described in terms of Ayurveda and is supported parallelly with the facts and findings of scientific researches done in modern science. JhMh can replace the side effects of chemical drugs and stand as sustainable antipyretics if used judicious.