Analysis on correlation between resistin -420C/G polymorphism and type 2 diabetes mellitus macroangiopathy in Han population of northeast China

M. Yan
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引用次数: 3

Abstract

Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.
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东北汉族抵抗素-420C/G多态性与2型糖尿病大血管病变的相关性分析
目的研究东北汉族人群RETN-420C/G单核苷酸多态性(snp)的等位基因和基因型频率分布及其与2型糖尿病(T2DM)合并大血管病变的关系。方法采用PCR-RFLP方法对60例T2DM合并大血管病变、60例单纯性T2DM和60例正常对照(ND)共180例患者的基因型及频率进行测定。结果T2DM合并大血管病变组的等位基因频率及单纯CC/GC+GG基因型与ND组比较差异有统计学意义(P0.01)。T2DM合并大血管病变组的等位基因频率及CC/GC+GG基因型与T2DM组比较差异有统计学意义(P0.05)。T2DM合并大血管病变组GC+GG基因型明显高于T2DM组(P0.05)。结论RETN-420C/G多态性与东北汉族T2DM合并大血管病变的发生有关。
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