Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.
{"title":"Analysis on correlation between resistin -420C/G polymorphism and type 2 diabetes mellitus macroangiopathy in Han population of northeast China","authors":"M. Yan","doi":"10.4236/JBM.2017.512003","DOIUrl":"https://doi.org/10.4236/JBM.2017.512003","url":null,"abstract":"Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86602696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.13229/J.CNKI.JDXBGXB201504019
Cong Wang, Sihu Li, Zhi-Gang Yang, Liu Guojun, Tian Zhao, Xu Yang
In order to improve the mixing efficiency of different reactants in microscale,a study on optimization of the structure and working parameters of the Y type pulsing micro mixer is conducted,in which the effects of the structure and parameters on mixing performance are taken into consideration.By simulation analysis,the channel section size,entrance angle,entrance flow rate and pulsation frequency are optimized.Based on the optimized structure and working parameters,a test prototype was made in lab.Using chemical reaction probe method,the prototype is tested.After detecting the size and distribution of gold nanoparticles by controllable synthesis,the mixing performance is evaluated synthetically.The test results indicate that when the entrance flow rate and working frequency are ascertained,there exist corresponding optimum values of the section size and flow rate of the Y type pulsing micro mixer.The entrance flow rate and working frequency are important parameters which influence each other.A certain flow rate corresponds to an optimum mixing frequency.
{"title":"Optimization of structure and working parameters of Y type micro-mixer in two-phase pulsating mixing","authors":"Cong Wang, Sihu Li, Zhi-Gang Yang, Liu Guojun, Tian Zhao, Xu Yang","doi":"10.13229/J.CNKI.JDXBGXB201504019","DOIUrl":"https://doi.org/10.13229/J.CNKI.JDXBGXB201504019","url":null,"abstract":"In order to improve the mixing efficiency of different reactants in microscale,a study on optimization of the structure and working parameters of the Y type pulsing micro mixer is conducted,in which the effects of the structure and parameters on mixing performance are taken into consideration.By simulation analysis,the channel section size,entrance angle,entrance flow rate and pulsation frequency are optimized.Based on the optimized structure and working parameters,a test prototype was made in lab.Using chemical reaction probe method,the prototype is tested.After detecting the size and distribution of gold nanoparticles by controllable synthesis,the mixing performance is evaluated synthetically.The test results indicate that when the entrance flow rate and working frequency are ascertained,there exist corresponding optimum values of the section size and flow rate of the Y type pulsing micro mixer.The entrance flow rate and working frequency are important parameters which influence each other.A certain flow rate corresponds to an optimum mixing frequency.","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91325011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.13481/J.1671-587X.20150426
Wu Xin
Objective To investigate the association between the single nucleotide polymorphisms(SNPs)of DNA methyltransferase 1(DNMT1)gene and the survival of the patients with gastric cancer after operation in the Han population from North China,and to clarify the association between the polymorphisms of DNMT1 gene and prognosis of gastric cancer.Methods A total of 447 gastric cancer patients treated with total gastrectomy were selected into the cohort study.The distribution of genotypic frequencies of five SNPs sites(rs16999593,rs10420321,rs2288349,rs2228611 and rs2228612)of DNMT1 were detected by TaqMan assay.447 cases of gastric cancer patients were followed up.Kaplan-Meier method was used to calculate the survival and draw the survival curves,and Log-rank test was used to compare the differences of overall survival(OS)between the patients with different genotypes.The hazardratio(HR)and 95% confidence interval(CI)were estimated by univariate and multivariate Cox regression analysis.Results Compared with the patients carried GG genotype at the rs2228611 site,the patients with GA/AA genotypes had better prognosis and Longer survival time(52.5months vs 42.9months,Log-rank P=0.006).After adjusting the confounding factors,the patients carried rs2228611GA/AA genotypes had a decreased death risk than the patients with GG genotype(HR 0.68,95% CI:0.50-0.92,P=0.013),suggesting that the polymorphisms of rs2228611 site was an independent influencing factor of prognosis of the patients with gastric cancer after operation.There was no association between the polymorphisms of other sites and the prognosis of gastric cancer.Conclusion The polymorphisms of DNMT1rs2228611GA/AA genotypes can prolong the survival time of the patients with gastric cancer.The polymorphism of DNMT1 could be used as a biomarker to predict the prognosis of gastric cancer.
{"title":"Influence of single nucleotide polymorphisms of DNMT1 gene in survival of patients with gastric cancer after operation","authors":"Wu Xin","doi":"10.13481/J.1671-587X.20150426","DOIUrl":"https://doi.org/10.13481/J.1671-587X.20150426","url":null,"abstract":"Objective To investigate the association between the single nucleotide polymorphisms(SNPs)of DNA methyltransferase 1(DNMT1)gene and the survival of the patients with gastric cancer after operation in the Han population from North China,and to clarify the association between the polymorphisms of DNMT1 gene and prognosis of gastric cancer.Methods A total of 447 gastric cancer patients treated with total gastrectomy were selected into the cohort study.The distribution of genotypic frequencies of five SNPs sites(rs16999593,rs10420321,rs2288349,rs2228611 and rs2228612)of DNMT1 were detected by TaqMan assay.447 cases of gastric cancer patients were followed up.Kaplan-Meier method was used to calculate the survival and draw the survival curves,and Log-rank test was used to compare the differences of overall survival(OS)between the patients with different genotypes.The hazardratio(HR)and 95% confidence interval(CI)were estimated by univariate and multivariate Cox regression analysis.Results Compared with the patients carried GG genotype at the rs2228611 site,the patients with GA/AA genotypes had better prognosis and Longer survival time(52.5months vs 42.9months,Log-rank P=0.006).After adjusting the confounding factors,the patients carried rs2228611GA/AA genotypes had a decreased death risk than the patients with GG genotype(HR 0.68,95% CI:0.50-0.92,P=0.013),suggesting that the polymorphisms of rs2228611 site was an independent influencing factor of prognosis of the patients with gastric cancer after operation.There was no association between the polymorphisms of other sites and the prognosis of gastric cancer.Conclusion The polymorphisms of DNMT1rs2228611GA/AA genotypes can prolong the survival time of the patients with gastric cancer.The polymorphism of DNMT1 could be used as a biomarker to predict the prognosis of gastric cancer.","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"277 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80063440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-01-01DOI: 10.13229/J.CNKI.JDXBGXB201401011
Wei Zhan, Q. Lü, Y. Shang
Based on the original data of traffic accidents in a typical highway tunnel group region, a grey forecasting model, which is modified by residual error model, is proposed to analyze the development trend of traffic accidents in highway tunnel group region. The forecasting accuracy is improved by introducing Markov optimization. Compared with commonly used forecasting method, the proposed method in this paper has a better forecasting accuracy and practicality in a period. It can be used for the forecasting analysis of traffic accidents and for security early warning in highway tunnel group region. Language: zh
{"title":"Analysis of gray-Markov forecasting for traffic accidents in highway tunnel group region","authors":"Wei Zhan, Q. Lü, Y. Shang","doi":"10.13229/J.CNKI.JDXBGXB201401011","DOIUrl":"https://doi.org/10.13229/J.CNKI.JDXBGXB201401011","url":null,"abstract":"Based on the original data of traffic accidents in a typical highway tunnel group region, a grey forecasting model, which is modified by residual error model, is proposed to analyze the development trend of traffic accidents in highway tunnel group region. The forecasting accuracy is improved by introducing Markov optimization. Compared with commonly used forecasting method, the proposed method in this paper has a better forecasting accuracy and practicality in a period. It can be used for the forecasting analysis of traffic accidents and for security early warning in highway tunnel group region. Language: zh","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"43 1","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81003900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The task allocation was studied based on the swarm inteeligence for the large-scale multi-robot system with loose-and tight-coupled tasks adopting the hierarchial architecture. In the high level,the ant colony algorithm was employed to find the optimal allocation of the loose-coupled tasks,namely,based on the reverse distribution idea,taking each ant to form a task,an undertaker was chosen for every task. In the low level,the coalition formation algorithms based on the ant colony optimization(ACO) ,the particle swarm and ant colomy optimization(PSACO) ,or the quantum-inspised ant colony optimization(QACO) was proposed respectively for performin a tight-coupled task.Simulations were performed and results showed that PSACO provides the best solution,but its running time is the largest;QACO is a little inferior in solution quality to PSACO,however,it needs only a half time of the 2 other methods. Therefore,QACO appears more suitable for the task allocation of the large-scale multi-robot system.
{"title":"Multi-Robot Task Allocation Based on Swarm Intelligence","authors":"Shuhua Liu, Tie-li Sun, C. Hung","doi":"10.5772/13106","DOIUrl":"https://doi.org/10.5772/13106","url":null,"abstract":"The task allocation was studied based on the swarm inteeligence for the large-scale multi-robot system with loose-and tight-coupled tasks adopting the hierarchial architecture. In the high level,the ant colony algorithm was employed to find the optimal allocation of the loose-coupled tasks,namely,based on the reverse distribution idea,taking each ant to form a task,an undertaker was chosen for every task. In the low level,the coalition formation algorithms based on the ant colony optimization(ACO) ,the particle swarm and ant colomy optimization(PSACO) ,or the quantum-inspised ant colony optimization(QACO) was proposed respectively for performin a tight-coupled task.Simulations were performed and results showed that PSACO provides the best solution,but its running time is the largest;QACO is a little inferior in solution quality to PSACO,however,it needs only a half time of the 2 other methods. Therefore,QACO appears more suitable for the task allocation of the large-scale multi-robot system.","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"341 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76396991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-01-01DOI: 10.4028/scientific5/amr.450-451.1616
Wang Lei
Combining with the stress characteristics of the foundation soil,the soil force was analyzed for finding the improved effect on the separated foundation bearing capacity of lateral fill.Establishing the calculation model and algorithm,the general formulation of separated foundation bearing capacity considering lateral fill was deduced.Then under direction of similarity theory,five model tests were designed to simulate the foundation deformation of silty clay in whole loading process.The pressure-settlement curves were drew and the foundation bearing capacity under lateral fill height of 0 m,4 m,8 m,12 m,16 m were measured.Test results showed that with the fill height increasing the bearing capacity increased significantly,it had been reached 885 kPa when the fill height was 12 m.But the growth was nonlinear,it firstly increased from 18.42% to 36.11% and then reduced to 3.39%.At last the bearing capacity reached 915 kPa while fill height reached 16m.Meanwhile the errors between the calculated results and measured by model test were almost less than 10%,so the algorithm was feasible.The conclusion is that the lateral fill is advantageous for improve the foundation bearing capacity and reduce project cost significantly when the settlement of the culverts foundation satisfied the design request,with the lateral fill increasing,the rate of the improvement first increases and then decreases,at last it tends to 915 kPa when fill height reached 16 m.
{"title":"Algorithm and Experimental of the Separated Foundation Bearing Capacity of Culverts Considering Lateral Fill","authors":"Wang Lei","doi":"10.4028/scientific5/amr.450-451.1616","DOIUrl":"https://doi.org/10.4028/scientific5/amr.450-451.1616","url":null,"abstract":"Combining with the stress characteristics of the foundation soil,the soil force was analyzed for finding the improved effect on the separated foundation bearing capacity of lateral fill.Establishing the calculation model and algorithm,the general formulation of separated foundation bearing capacity considering lateral fill was deduced.Then under direction of similarity theory,five model tests were designed to simulate the foundation deformation of silty clay in whole loading process.The pressure-settlement curves were drew and the foundation bearing capacity under lateral fill height of 0 m,4 m,8 m,12 m,16 m were measured.Test results showed that with the fill height increasing the bearing capacity increased significantly,it had been reached 885 kPa when the fill height was 12 m.But the growth was nonlinear,it firstly increased from 18.42% to 36.11% and then reduced to 3.39%.At last the bearing capacity reached 915 kPa while fill height reached 16m.Meanwhile the errors between the calculated results and measured by model test were almost less than 10%,so the algorithm was feasible.The conclusion is that the lateral fill is advantageous for improve the foundation bearing capacity and reduce project cost significantly when the settlement of the culverts foundation satisfied the design request,with the lateral fill increasing,the rate of the improvement first increases and then decreases,at last it tends to 915 kPa when fill height reached 16 m.","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74789999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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