Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis

Zhen Xiong, P. Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, B. Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Z. Fan
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引用次数: 8

Abstract

Xiong et al. show that CCP3 performs deglutamylation of BAP1 to stabilize BAP1, which eliminates H2AK119Ub from Hoxa1 promoter and initiates Hoxa1 expression, leading to enhanced HSC self-renewal.
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去泛素酶BAP1的谷氨酰化控制造血干细胞的自我更新和造血
Xiong等人的研究表明,CCP3通过BAP1的去谷氨酰化来稳定BAP1,从而消除Hoxa1启动子中的H2AK119Ub,启动Hoxa1表达,从而增强HSC自我更新。
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