R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami
{"title":"ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons","authors":"R. Hasebe, K. Murakami, Masaya Harada, N. Halaka, H. Nakagawa, F. Kawano, Y. Ohira, T. Kawamoto, F. Yull, T. Blackwell, J. Nio-Kobayashi, Toshihiko Iwanaga, Masahiko Watanabe, N. Watanabe, H. Hotta, T. Yamashita, D. Kamimura, Yuki Tanaka, M. Murakami","doi":"10.1084/jem.20212019","DOIUrl":null,"url":null,"abstract":"Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"50 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Tokushima journal of experimental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20212019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
Local inflammation spreads to remote positions via sensory neuron–interneuron crosstalk using ATP. This neural pathway, or remote inflammation gateway reflex, may be a therapeutic target for inflammatory diseases with remote inflammation, such as rheumatoid arthritis.
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